BDBM13595 ({4-[2-(1H-1,2,3-benzotriazol-1-yl)-3-{4-[difluoro(phosphono)methyl]phenyl}-2-phenylpropyl]phenyl}difluoromethyl)phosphonic acid::Aryldifluoromethyl-Phosphonic Acid Inhibitor 2::CHEMBL276647

SMILES OP(O)(=O)C(F)(F)c1ccc(CC(Cc2ccc(cc2)C(F)(F)P(O)(O)=O)(c2ccccc2)n2nnc3ccccc23)cc1

InChI Key InChIKey=WNNXXNZHCLRWMD-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 13595   

TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Merck Research Laboratories

LigandPNGBDBM13595(CHEMBL276647 | ({4-[2-(1H-1,2,3-benzotriazol-1-yl)...)
Affinity DataIC50: 16nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Merck Research Laboratories

LigandPNGBDBM13595(CHEMBL276647 | ({4-[2-(1H-1,2,3-benzotriazol-1-yl)...)
Affinity DataIC50: 11nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM13595(CHEMBL276647 | ({4-[2-(1H-1,2,3-benzotriazol-1-yl)...)
Affinity DataIC50: 120nMAssay Description:Inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) over-expressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM13595(CHEMBL276647 | ({4-[2-(1H-1,2,3-benzotriazol-1-yl)...)
Affinity DataIC50: 16nMAssay Description:Inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) over-expressed in intact Sf9 cell assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM13595(CHEMBL276647 | ({4-[2-(1H-1,2,3-benzotriazol-1-yl)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Merck Research Laboratories

LigandPNGBDBM13595(CHEMBL276647 | ({4-[2-(1H-1,2,3-benzotriazol-1-yl)...)
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed