BDBM120158 US8691753, 6

SMILES NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)CCc1cc(no1)-c1ccc(cc1)-c1cccc(Cl)c1

InChI Key InChIKey=KOVQMCGGWATESY-UHFFFAOYSA-N

Data  18 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 120158   

TargetMacrophage metalloelastase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  8.30nMAssay Description:Inhibition of human MMP-12 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCollagenase 3(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  40nMAssay Description:Inhibition of human MMP-13 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetStromelysin-2(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  48nMAssay Description:Inhibition of human MMP-10 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetStromelysin-1(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  62nMAssay Description:Inhibition of human MMP-3 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails
PubMed
Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  76nMAssay Description:Inhibition of human MMP-2 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNeutrophil collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  181nMAssay Description:Inhibition of human MMP-8 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCollagenase 3(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  235nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMacrophage metalloelastase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  401nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target72 kDa type IV collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  403nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetStromelysin-2(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  489nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  565nMAssay Description:Inhibition of human MMP-9 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetStromelysin-1(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMatrilysin(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of human MMP-7 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMatrix metalloproteinase-14(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  2.06E+3nMAssay Description:Inhibition of human MMP-14 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetMatrix metalloproteinase-9(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi: >5.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeutrophil collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi: >5.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetMatrix metalloproteinase-14 [1-20,P8S](Human)
French Alternative Energies and Atomic Energy Commission

US Patent
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi: >1.00E+4nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetInterstitial collagenase(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM120158(US8691753, 6)
Affinity DataKi:  1.79E+4nMAssay Description:Inhibition of human MMP-1 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In DepthDetails
PubMed