BDBM120086 US8697715, 1::US9259470, 1

SMILES OC[C@H](c1ccc(Cl)c(F)c1)n1ccc(cc1=O)-c1ccnc(NC2CCOCC2)n1

InChI Key InChIKey=PGGLRAWFUJMQBN-UHFFFAOYSA-N

Data  1 KI  12 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 120086   

TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 3.90nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 3.90nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 3(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataKi:  0.600nMAssay Description:Inhibition of 6-His tagged human ERK2 expressed in Escherichia coli measured over 30 mins by competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)