BDBM11442 5-chloro-N-(4-methanesulfonylphenyl)pyrazolo[1,5-a]pyrimidin-7-amine::sulfonylphenylamino analogue 8a

SMILES CS(=O)(=O)c1ccc(Nc2cc(Cl)nc3ccnn23)cc1

InChI Key InChIKey=LVNXHNRYPADEAD-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 11442   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11442(5-chloro-N-(4-methanesulfonylphenyl)pyrazolo[1,5-a...)
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Rat)
Martin-Luther-University Halle-Wittenberg

LigandPNGBDBM11442(5-chloro-N-(4-methanesulfonylphenyl)pyrazolo[1,5-a...)
Affinity DataIC50: 3.10E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed