BDBM11324 (2R,3R,4S,5R)-2-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol::5,6-Dichloro-1-.beta.-D-ribofuranosylbenzimidazole::5,6-dichloro-ribofuranosylbenzimidazole::CHEMBL375530::DRB

SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2cc(Cl)c(Cl)cc12

InChI Key InChIKey=XHSQDZXAVJRBMX-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 11324   

TargetCasein kinase II subunit alpha(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM11324(CHEMBL375530 | (2R,3R,4S,5R)-2-(5,6-dichloro-1H-1,...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of GST-fused human recombinant CK2alpha expressed in Escherichia coli HMS174 (DE3)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM11324(CHEMBL375530 | (2R,3R,4S,5R)-2-(5,6-dichloro-1H-1,...)
Affinity DataKi:  340nMAssay Description:Inhibition of CDK9/Cyclin T (1 to 330 amino acid residues) (unknown origin) by differential scanning fluorimetry assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM11324(CHEMBL375530 | (2R,3R,4S,5R)-2-(5,6-dichloro-1H-1,...)
Affinity DataKi:  4.50E+3nM ΔG°:  -7.22kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCasein kinase II subunit beta(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM11324(CHEMBL375530 | (2R,3R,4S,5R)-2-(5,6-dichloro-1H-1,...)
Affinity DataKi:  2.30E+4nMAssay Description:Binding affinity to CK2beta (unknown origin) using casein as substrate in presence of [gamma-32p]-GTP by liquid scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM11324(CHEMBL375530 | (2R,3R,4S,5R)-2-(5,6-dichloro-1H-1,...)
Affinity DataKi:  6.50E+4nMAssay Description:Inhibition of CDK2/Cyclin A (174 to 432 amino acid residues) (unknown origin) by differential scanning fluorimetry assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed