BDBM11316 1,8-dihydroxy-9,10-dihydroanthracene-9,10-dione::1,8-dihydroxy-anthraquinone::Anthraquinone-related compound::CHEMBL53418

SMILES Oc1cccc2C(=O)c3cccc(O)c3C(=O)c12

InChI Key InChIKey=QBPFLULOKWLNNW-UHFFFAOYSA-N

Data  1 KI  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 11316   

Target5-lipoxygenase(Bovine)
WestfäLische Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM11316(1,8-dihydroxy-anthraquinone | 1,8-dihydroxy-9,10-d...)
Affinity DataIC50: 3.00E+4nMAssay Description:5-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSialidase-2(Human)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM11316(1,8-dihydroxy-anthraquinone | 1,8-dihydroxy-9,10-d...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human Neu2 assessed as MuNANA substrate hydrolysis in presence of 0.1% Triton X-100 by discontinuous fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThioredoxin reductase 1, cytoplasmic(Rat)
University of Padova

Curated by ChEMBL
LigandPNGBDBM11316(1,8-dihydroxy-anthraquinone | 1,8-dihydroxy-9,10-d...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of rat liver cytosolic TrxR1 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThioredoxin reductase 2, mitochondrial(Rat)
University of Padova

Curated by ChEMBL
LigandPNGBDBM11316(1,8-dihydroxy-anthraquinone | 1,8-dihydroxy-9,10-d...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of rat liver mitochondrial TrxR2 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM11316(1,8-dihydroxy-anthraquinone | 1,8-dihydroxy-9,10-d...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
North-West University

Curated by ChEMBL
LigandPNGBDBM11316(1,8-dihydroxy-anthraquinone | 1,8-dihydroxy-9,10-d...)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
North-West University

Curated by ChEMBL
LigandPNGBDBM11316(1,8-dihydroxy-anthraquinone | 1,8-dihydroxy-9,10-d...)
Affinity DataIC50: 5.87E+4nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by fluorescence ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCasein kinase II subunit alpha(Maize)
University of Padova

LigandPNGBDBM11316(1,8-dihydroxy-anthraquinone | 1,8-dihydroxy-9,10-d...)
Affinity DataKi: >4.00E+4nM ΔG°: >-5.94kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed