BDBM113069 US9695194, 5
SMILES CCOc1cc2c(cc1OC)nc(oc2=O)-c1ccccc1OC
InChI Key InChIKey=MICLUGCMNGFNIQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 113069
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant human KLK7 using S-2586 substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human KLK5 using S-2288 substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human KLK14 using S-2302 substrateMore data for this Ligand-Target Pair
Affinity DataKi: 85nM ΔG°: -10.0kcal/molepH: 7.2 T: 2°CAssay Description:Materials: Recombinant human KLK7, Substrate S-2586 (Chromogenics, cat. no. 820894) KLK7 activity was determined at 37° C. in 10 mM Na phosphate ...More data for this Ligand-Target Pair
Affinity DataKi: 300nM ΔG°: -9.25kcal/molepH: 8.0 T: 2°CAssay Description:Materials: Recombinant human KLK14, Substrate S-2302 (Chromogenics, cat. no. 820340). KLK14 activity was determined at 37° C. in 0.1 mM Tris, pH ...More data for this Ligand-Target Pair
Affinity DataKi: 500nM ΔG°: -8.94kcal/molepH: 8.0 T: 2°CAssay Description:Materials: Recombinant human KLK5, Substrate S-2288 (Chromogenics, cat. no. 820852) KLK5 activity was determined at 37° C. in 0.1 M Tris, pH 8.0,...More data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nM ΔG°: -8.40kcal/molepH: 7.2 T: 2°CAssay Description:Materials: Cathepsin G, 100 mU (VWR, Calbiochem, cat. no. 219373), Substrate Cathepsin G substrate (VWR, Calbiochem, cat. no. 219407). Cathepsin acti...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nM ΔG°: >-7.09kcal/molepH: 7.2 T: 2°CAssay Description:Materials: Chymotrypsin, bovine, 25 ug (Roche, sequence grade), Substrate S-2586 (Chromogenics, cat. no. 82 08 94). Chymotrypsin activity was determi...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nM ΔG°: >-7.09kcal/molepH: 7.2 T: 2°CAssay Description:Materials: Trypsin, 100 ug (Roche, sequence grade, Mw 23500), Substrate S-2288 (Chromogenics, cat. no. 820852). Trypsin activity was determined at 3...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nM ΔG°: >-7.09kcal/molepH: 8.3 T: 2°CAssay Description:Materials: Thrombin (Chromogenics, cat. no. 820712), Substrate S-2288 (Chromogenics, cat. no. 82 08 52). Thrombin activity was determined at 37° ...More data for this Ligand-Target Pair