BDBM10894 4-(4-tert-Butylphenylcarboxamidomethyl)benzenesulfonamide::4-tert-butyl-N-[(4-sulfamoylphenyl)methyl]benzamide::aromatic/heteroaromatic sulfonamide 28

SMILES CC(C)(C)c1ccc(cc1)C(=O)NCc1ccc(cc1)S(N)(=O)=O

InChI Key InChIKey=MLMBOLOCASDIAK-UHFFFAOYSA-N

Data  3 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 10894   

TargetBifunctional epoxide hydrolase 2(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM10894(4-tert-butyl-N-[(4-sulfamoylphenyl)methyl]benzamid...)
Affinity DataIC50: 280nMAssay Description:Inhibition of recombinant human sEH using PHOME as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile acid receptor(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandPNGBDBM10894(4-tert-butyl-N-[(4-sulfamoylphenyl)methyl]benzamid...)
Affinity DataEC50:  1.40E+3nMAssay Description:Transactivation of human FXR expressed in human HeLa cells co-expressing BSEP after 24 hrs by dual-glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCARBONIC ANHYDRASE(Helicobacter pylori (strain J99 / ATCC 700824) (Ca...)
Kochi Medical School

LigandPNGBDBM10894(4-tert-butyl-N-[(4-sulfamoylphenyl)methyl]benzamid...)
Affinity DataKi:  62nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 2(Human)
Kochi Medical School

LigandPNGBDBM10894(4-tert-butyl-N-[(4-sulfamoylphenyl)methyl]benzamid...)
Affinity DataKi:  127nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarbonic anhydrase 1(Human)
Kochi Medical School

LigandPNGBDBM10894(4-tert-butyl-N-[(4-sulfamoylphenyl)methyl]benzamid...)
Affinity DataKi:  1.33E+4nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed