BDBM10881 CHEMBL288100::MZA3::Methazolamide::Methazolamide (MZA)::Methazolamide, MZA::N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide::Sulfonamide, 2::cid_4100::sulfonamide 2
SMILES CC(=O)N=c1sc(nn1C)S(N)(=O)=O
InChI Key InChIKey=FLOSMHQXBMRNHR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 300 hits for monomerid = 10881
Affinity DataIC50: 12.5nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 205nMAssay Description:The assay measured the rate of CO2 hydration by determining the addition rate of a NaOH solution using a Radiometer VIT 90 titration system. The enzy...More data for this Ligand-Target Pair
Affinity DataIC50: 14nM EC50: 40nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
TargetCorticotropin-releasing factor-binding protein(Human)
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataEC50: >5.30E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibitory activity of compound against human carbonic anhydrase IIMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibitory activity of compound against bovine carbonic anhydrase IVMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibitory activity of compound against human carbonic anhydrase IMore data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.25nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibition of human carbonic anhydrase 3More data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 2.10nM ΔG°: -11.8kcal/molepH: 7.4 T: 2°CAssay Description:Carbonic anhydrase (CA) inhibition against hCA II and V11 with synthesized compounds 2-8.More data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Ki value against human carbonic anhydrase VIIMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Inhibition of human carbonic anhydrase 7More data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Inhibition of human recombinant full length CA7 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Inhibition of human full length carbonic anhydrase 7 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition assay using carbonic anhydrases.More data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition constant against human carbonic anhydrase XIMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition of human cloned CA12 catalytic domain by CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition of human cloned catalytic domain of CA12 after 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibitory activity against catalytic domain of human carbonic anhydrase XIIMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibitory constant against catalytic domain of human carbonic anhydrase XIIMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Ki value against human carbonic anhydrase XII (hCA XII)More data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibitory activity against cloned human CA12More data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition of human recombinant CA12 by CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition of human recombinant CA12 by CO2 hydration stopped flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition of human carbonic anhydrase 12More data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition of human recombinant CA12 catalytic domain by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition of human catalytic domain carbonic anhydrase 12 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Inhibitory activity against human carbonic anhydrase IIMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of full length human recombinant CA VIMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of human carbonic anhydrase 6More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of human recombinant full length CA6 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of human full length carbonic anhydrase 6 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 14nM ΔG°: -10.6kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
Affinity DataKi: 14nM ΔG°: -10.7kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 14nM ΔG°: -10.7kcal/molepH: 7.4 T: 2°CAssay Description:Carbonic anhydrase (CA) inhibition against hCA II and V11 with synthesized compounds 2-8.More data for this Ligand-Target Pair