BDBM50242374 CHEMBL505529::topostatin

SMILES CCCCCCCC(C)CC=C(C)C=CC(=O)C(C)CCC1OC(=O)[C@H](CC(OS(O)(=O)=O)C(N)=O)NC(=O)[C@@H](C)CNC(=O)C(=C)NC(=O)C1C

InChI Key InChIKey=XLDIAUNLPWGNHO-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50242374   

TargetDeoxyribonuclease-1(Bovine)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of bovine pancreas DNase 1 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTelomerase reverse transcriptase(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of telomerase from human COLO201 cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetType II restriction enzyme ScaI(Streptomyces caespitosus)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Streptomyces caespitosus Sca 1 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetType II restriction enzyme PstI(Providencia stuartii)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of Providencia stuartii Pst 1 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetType II restriction enzyme HindIII(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of Haemophilus influenzae Hind 3 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetType II restriction enzyme EcoRI(Escherichia coli)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of Escherichia coli Eco R1 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetType II restriction enzyme BamHI(Bacillus amyloliquefaciens)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 1.85E+5nMAssay Description:Inhibition of Bacillus amyloliquifaction Bam H1 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA ligase(Enterobacteria phage T4)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of T4 ligase from bacteriophage infected Escherichia coli assessed as ligation of supercoiled pBR322 DNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDeoxyribonuclease-2-alpha(Pig)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of porcine spleen DNase 2 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase(Bovine)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition calf thymus gland topoisomerase 1 assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRibonuclease pancreatic(Bovine)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of bovine pancreas RNase A assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition human placenta topoisomerase 2 assessed as conversion of catenated kinetoplast DNA to minicircle monomerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition human placenta topoisomerase 2 assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition topoisomerase 1 in human HeLa cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition topoisomerase 1 in human COLO201 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition topoisomerase 1 in human A549 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Green monkey)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition topoisomerase 1 in african green monkey Vero cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed