BDBM50004058 (2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid::N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine::N-(butylsulfonyl)-O-(4-piperidin-4-ylbutyl)-L-tyrosine::tirofiban
SMILES CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(O)=O
InChI Key InChIKey=COKMIXFXJJXBQG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 41 hits for monomerid = 50004058
Affinity DataIC50: 90nMAssay Description:Antagonist activity at GP2b/GP3a receptor in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of aggregation of human gel-filtered platelets measured by light transmittance method at 37 degrees C.More data for this Ligand-Target Pair
Affinity DataIC50: 0.370nMAssay Description:Displacement of biotinylated fibrinogen from human glycoprotein 2b/3a receptor after 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.950nMAssay Description:Inhibition of fibrinogen binding to Integrin alpha2bbeta3 receptor (unknown origin) by competitive ELISAMore data for this Ligand-Target Pair
Affinity DataKd: 13nMAssay Description:Binding affinity against alpha IIb beta-3 integrin in the presence of L-736622.More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:In vitro inhibition of ADP-mediated human gel filtered platelet aggregation.More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+5nMAssay Description:Inhibition of HUVEC attachment to human fibrinogenMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of HUVEC attachment to human fibronectinMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HUVEC attachment to human vitronectinMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of [125I]fibrinogen binding to fibrinogen receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Displacement of fibrinogen from human platelet GP2b/GP3a receptor after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataKd: 1.90nMAssay Description:Competition with [1251]L-692,884 for binding to purified alpha IIb/beta3 integrin, activated by coating onto yttrium silicate scintillation proximity...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of ADP-mediated platelet aggregation in human gel-filtered plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human fibronectin binding to human Integrin alpha2b beta3 receptor incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human integrin alphavbeta3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of fibrinogen binding to human platelet integrin alpha2b beta3 by ELISA based solid phase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Binding affinity to human integrin alpha2bbeta3 incubated for 1 hr by ELISA based solid phase integrin binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMAssay Description:Inhibition of fibrinogen binding to alpha2bbeta3 isolated from human HEL cells incubated for 1 hr by scintillation-proximity assay based competitive ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Antagonist activity at alpha2bbeta3 in human HEL cells assessed as reduction in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinog...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of fibrinogen binding to rat platelet integrin alpha2b beta3 by ELISA based solid phase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 136nMAssay Description:Inhibition of fibrinogen binding to rat platelet integrin alpha2b beta3 by ELISA based solid phase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human umbilical vein endothelial cell adhesion to fibronectinMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Binding affinity to alpha2b/beta3 integrin (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of fibrinogen binding to human alpha2b/beta3 integrin after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:The compound was tested in vivo for the inhibition of aggregation of human gel-filtered platelets(GFP)More data for this Ligand-Target Pair
Affinity DataKd: 15nMAssay Description:Equilibrium dissociation constant was measured from displacement of L-762,745 from Fibrinogen receptor of human platelets by flow cytometryMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human alphaIIb-beta3 integrin in platelet aggregation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of binding to human Vitronectin receptor (integrin alphaV-beta3)More data for this Ligand-Target Pair
TargetIntegrin alpha-2/beta-3(Human)
A.V. Bogatsky Physico-Chemical Institute of The National Academy of Sciences of Ukraine
Curated by ChEMBL
A.V. Bogatsky Physico-Chemical Institute of The National Academy of Sciences of Ukraine
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Antagonist activity against integrin alpha2bbeta3 open form in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
TargetIntegrin alpha-2/beta-3(Human)
A.V. Bogatsky Physico-Chemical Institute of The National Academy of Sciences of Ukraine
Curated by ChEMBL
A.V. Bogatsky Physico-Chemical Institute of The National Academy of Sciences of Ukraine
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Antagonist activity against integrin alpha2bbeta3 closed form in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregatio...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of FITC-labelled fibrinogen binding to integrin alpha2b beta3 receptor in human platelet cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of FITC-labeled fibrinogen binding to integrin alpha2bbeta3 receptor in human platelets by flow cytometryMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+5nMAssay Description:Inhibition of human umbilical vein endothelial cell adhesion to fibrinogenMore data for this Ligand-Target Pair
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of human umbilical vein endothelial cell adhesion to vitronectinMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light. More data for this Ligand-Target Pair
Affinity DataIC50: 0.370nMAssay Description:Displacement of biotinylated fibrinogen from human alpha2b-beta3 receptor after 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.950nMAssay Description:Displacement of extracellular matrix protein fibrinogen from human integrin alpha2bbeta3 after 1 hr by competitive ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 13.6nMAssay Description:Inhibition of integrin alpha2bbeta3-mediated platelet aggregation in human TRAP-6-activated whole blood for 6 mins by impedence-based aggregometryMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Compound was evaluated for inhibition against Fibrinogen Receptor.More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of platelet aggregationMore data for this Ligand-Target Pair
Affinity DataKd: 13nMAssay Description:Binding affinity to resting form of alpha IIb/beta3 integrin by flow cytometry using fluorescein ligand L-726,745 displacement from human platelets.More data for this Ligand-Target Pair