BDBM50240416 CHEMBL23838::O,O-diethyl O-p-nitrophenyl phosphate::diethyl 4-nitrophenyl phosphate::diethyl p-nitrophenyl phosphate::diethyl paraoxon::ethyl paraoxon::p-nitrophenyl diethyl phosphate::paraoxon::phosphacol::phosphoric acid diethyl 4-nitrophenyl ester

SMILES CCOP(=O)(OCC)Oc1ccc(cc1)[N+]([O-])=O

InChI Key InChIKey=WYMSBXTXOHUIGT-UHFFFAOYSA-N

Data  2 KI  11 IC50  1 Kd  3 Kon

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50240416   

TargetFatty-acid amide hydrolase 1(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataIC50: 540nMAssay Description:Inhibition of FAAH-mediated [3H]anandamide hydrolysis in mouse brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
The University of Montana

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataKoff:  333s-1Assay Description:Inhibition of electric eel AChE by concentration-dependent inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
The University of Montana

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataKoff:  267s-1Assay Description:Inhibition of rat brain AChE by concentration-dependent inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
The University of Montana

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataKoff:  567s-1Assay Description:Inhibition of rat brain AChE by time-dependent inhibition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human AChE using p-nitrophenyl acetate as substrate measured for 30 secs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
The University of Montana

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataKd:  1.70E+5nMAssay Description:Binding affinity to Electric eel AChE using acetylthiocholine as substrate measured for 30 secs by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human BChE using butyrylthiocholine as substrate measured for 30 secs by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 13(Mouse)
Università

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of esterase activity of mouse carbonic anhydrase 13 by CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataIC50: 59nMAssay Description:Inhibition of esterase activity of human carbonic anhydrase 2 by CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Università

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataIC50: 338nMAssay Description:Inhibition of esterase activity of human carbonic anhydrase 1 by CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataIC50: 13nMAssay Description:Displacement of acetylcholine from AChE in Swiss Webster mouse brain after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataIC50: 5.90E+3nMAssay Description:Displacement of [3H]anandamide from FAAH in Swiss Webster mouse brain after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of 2-arachidonylglycerol from MAGL in Swiss Webster mouse brain after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [3H]CP-55940 from CB1 receptor in mouse brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of California

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor DM1(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]QNB from Drosophila melanogaster mAChR by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor DM1(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM50240416(diethyl 4-nitrophenyl phosphate | paraoxon | O,O-d...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]AF-DX 384 from Drosophila melanogaster mAChR by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed