BDBM50014846 (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide::(S)-colchicine::7alphaH-colchicine::CHEMBL107::COLCHICINE::N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide::colchicina::colchicinum
SMILES COc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC
InChI Key InChIKey=IAKHMKGGTNLKSZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 88 hits for monomerid = 50014846
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of tubulin polymerization in porcine brainMore data for this Ligand-Target Pair
Affinity DataIC50: 2.68E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetryMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Illinois
Curated by ChEMBL
University of Illinois
Curated by ChEMBL
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
Affinity DataKd: 3.70E+3nMAssay Description:Binding affinity to porcine tubulin after 1 hr by spectrofluorometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of pig brain tubulin polymerization in presence of GTP by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:Inhibition of porcine brain tubulin polymerization measured every 1 min for 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization assessed as reduction in GTP-induced microtubule assembly after 60 mins by OD340 methodMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of bovine brain tubulin polymerization (ITP).More data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Tested for inhibition against tubulin polymerizationMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of Tubulin polymerization by a 40 uM solution of compound; compound showed inhibition >50% at 40 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+3nMAssay Description:Displacement of [3H]Colchicine from pig biotinylated tubulin after 2 hrs by SPAMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization measured every 30 sec for 30 mins by spectrophotometryMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of tubulin polymerization using isolated calf brain at 26 degrees CMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of tubulin polymerization using isolated calf brain at 37 degrees CMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibition of maximum porcine tubulin assembly rate after 20 min at 37 degrees CMore data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+3nMAssay Description:In vitro inhibitory concentration required to displace [3H]colchicine from its binding site on tubulinMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human PIM1 measured after 5 mins by ELISA relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 6.93E+3nMAssay Description:Inhibition of tubulin beta polymerization in human MCF7 cells after 18 to 24 hrs by ELISA based spectrophotometric analysisMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 0 group B member 1(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization incubated for 60 mins by fluorescence-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization measured for 30 mins in presence of GTP by microplate reader assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.05E+3nMAssay Description:Inhibition of pig brain tubulin polymerization in the presence of GTP by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of tubulin polymerization of pig brain by absorbance based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.42E+3nMAssay Description:Inhibition of tubulin polymerization of pig brain microtubules by spectroscopic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of porcine brain tubulin polymerization preincubated for 1 mins followed by GTP addition and measured for 60 mins at 1 min interval by flu...More data for this Ligand-Target Pair
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrometric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrophotometeric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of pig brain tubulin polymerization in the presence of GTP by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of pig brain tubulin polymerization by spectrometric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization after 20 mins in presence of GTP by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataKd: 1.13E+4nMAssay Description:Binding affinity to porcine brain tubulin polymerization by surface plasmon analysis analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of pig brain tubulin polymerization measured every 1 min for 25 mins by spectrophotometric methodMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1(Bovine)
University of North Carolina At Chapel Hill
Curated by ChEMBL
University of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization measured every 30 secs for 30 mins by turbidimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.85E+3nMAssay Description:Binding affinity to pig brain tubulin polymerization measured every 1 mins of 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetry analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+3nMAssay Description:Displacement of [3H]colchicine from biotinylated pig brain tubulin after 2 hrs by competitive scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of porcine brain tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of pig tubulin polymerization determined after 45 mins at 37 degC by turbidimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant human HDAC1 expressed in baculovirus infected insect High5 cells using Ac-Lys-Tyr-Lys (epsilon-acetyl)-AMC as substrate aft...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Tested for 50 % inhibition of tubulin polymerization by turbidimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Compound was evaluated for in vitro inhibitory activity against polymerization of tubulin into microtubules isolated from bovine brain at 1 mg/mL tub...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:The compound was evaluated in vitro for the mammalian brain tubulin polymerization using standard assay.More data for this Ligand-Target Pair