BDBM46858 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid methyl ester;hydrobromide::ARECOLINE::ARECOLINE HYDROBROMIDE::MLS000028840::SMR000058258::arecoline;hydrobromide::cid_9301::methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide
SMILES COC(=O)C1=CCCN(C)C1
InChI Key InChIKey=HJJPJSXJAXAIPN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 92 hits for monomerid = 46858
Affinity DataIC50: 115nMAssay Description:Ability to displace [3H]oxotremorine from Muscarinic acetylcholine receptor M1 expressed in CHO cells.More data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+5nMAssay Description:Displacement of [3H]QNB from muscarinic M1 receptor in Wistar rat brain cortex after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Illinois
Curated by ChEMBL
University of Illinois
Curated by ChEMBL
Affinity DataIC50: 1.28E+6nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
Affinity DataIC50: 4.69E+5nMAssay Description:Displacement of [3H]QNB from muscarinic M1 receptor in Wistar rat brain cortex membrane after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.19E+4nMAssay Description:Compound was evaluated for the displacement of the muscarinic QNB in a genetically transformed rat cell line (m1c2) transfected with cloned m1 recept...More data for this Ligand-Target Pair
Affinity DataIC50: 9.15E+3nMAssay Description:Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart)More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]-Pz (pirenzepine) from the muscarinic receptor M1 of the rat hippocampusMore data for this Ligand-Target Pair
Affinity DataIC50: 4.69E+5nMAssay Description:Displacement of [3H]Quinuclidinyl benzilate from muscarinic M1 receptor in Wistar rat cortex synaptosomal membraneMore data for this Ligand-Target Pair
Affinity DataEC50: 5.60E+3nMAssay Description:Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2.54E+4nMAssay Description:In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
TargetMucolipin-3(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataEC50: 2.26E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]-(R)-QNB binding to muscarinic receptors of rat brain membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetyl...More data for this Ligand-Target Pair
Affinity DataIC50: 1.45E+5nMAssay Description:Compound was evaluated for its ability to displace [3H]N-methylscopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcho...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membraneMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H](R)-QNB binding to muscarinic receptor in rat brain membranesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligandMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of binding of radioactive N-propylbenzilycholine mustard ([3H]-PrBCM) to rat brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Displacement of [3H]oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Ability to displace [3H]cis--2-methyl-5-((dimethylamino)methyl)-1,3-di oxolane from muscarinic acetylcholine receptor in rat cortical tissue.More data for this Ligand-Target Pair
Affinity DataEC50: 73nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
Affinity DataIC50: 1.74E+3nMAssay Description:Evaluated for inhibition of binding of [3H]pirenzepine to homogenized rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Displacement of [3H]-OXO-M (oxotremorine-M) from the central muscarinic receptor sites of the rat brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 4.75E+4nMAssay Description:Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acety...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2.54E+4nMAssay Description:In vitro inhibition of [3H]QNB binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]OXO-M as the radioligand.More data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+4nMAssay Description:Tested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of [3H]pirenzepine binding to rat brain membrane Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+4nMAssay Description:Stimulation of cAMP in CHO cells expressing human m2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.16E+5nMAssay Description:Ability to displace [3H]N-methylscopolamine from Muscarinic acetylcholine receptor M1 expressed in CHO cells.More data for this Ligand-Target Pair
Affinity DataEC50: 3.20E+3nMAssay Description:In Vitro evaluation activity at the cloned Human Muscarinic acetylcholine receptor M1 determined by receptor selection and amplification technology (...More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).More data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+4nMAssay Description:Compound was evaluated for its ability to displace [3H]N-methylscopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcho...More data for this Ligand-Target Pair
Affinity DataEC50: 600nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)More data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M4 determined by receptor selection and amplification technology (R-SAT)More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]-Pz as the radioligand.More data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropineMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:In vitro binding affinity to muscarinic acetylcholine receptor site in rat brain assayed using [3H]oxotremorine-M as the radioligand.More data for this Ligand-Target Pair
Affinity DataEC50: 340nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.06E+5nMAssay Description:In Vitro binding affinity to the muscarinic acetylcholine receptor site in rat brain by using [3H]QNB as the radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 545nMAssay Description:Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferensMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:In vitro binding affinity against M1 receptor from rat hippocampus, using [3H]oxotremorine-M (Oxo-M) as radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 1.74E+3nMAssay Description:Ability to displace [3H]pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue.More data for this Ligand-Target Pair