BDBM120262 EDROPHONIUM BROMIDE::EDROPHONIUM CHLORIDE::Edrophonium::Edrophonium Chloride, 3::cid_8307

SMILES CC[N+](C)(C)c1cccc(O)c1

InChI Key InChIKey=VWLHWLSRQJQWRG-UHFFFAOYSA-O

Data  13 KI  14 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 120262   

TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 200nMAssay Description:Inhibition of Acetylcholinesterase from human red blood cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 780nMAssay Description:Inhibition acetylcholinesterase (AChE) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
University of Siena

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 5.36E+3nMAssay Description:Inhibition of bovine AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 780nMAssay Description:Inhibitory activity against AcetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Defence

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 1.37E+6nMAssay Description:Inhibition of human plasmatic BChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Defence

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 1.37E+6nMAssay Description:Inhibition of human plasmatic BChE by modified Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human erythrocyte recombinant AChE by modified Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 5.17E+3nMAssay Description:Inhibition of human recombinant AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 3.96E+3nMAssay Description:In vitro inhibitory activity against human recombinant AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein(WNV)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 5.00E+4nMAssay Description:The HTS assay to identify Inhibitors of West Nile Virus (WNV) NS2bNS3 Proteinase was proposed by Dr Alex Strongin of the Burnham Institute XO1-MH0776...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetAcetylcholinesterase(Bovine)
University of Siena

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 50nMAssay Description:Inhibition of Acetylcholinesterase activity of calf forebrainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 5.17E+3nMAssay Description:Inhibition of human recombinant AChE after 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Defence

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 1.37E+6nMAssay Description:Inhibition of human plasmatic BChE after 5 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataIC50: 500nMAssay Description:Inhibition of Acetylcholinesterase activity from octopus brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataKi:  1.60nMAssay Description:Inhibition constant determined against Acetylcholinesterase (AChE) receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataKi:  200nMAssay Description:Binding affinity against Acetylcholinesterase of human RBCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
University of Siena

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataKi:  200nMAssay Description:Binding affinity against Acetylcholinesterase of purified calf forebrain (CFB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Mouse)
Mayo Clinic

LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataKi:  250nM ΔG°:  -9.00kcal/molepH: 7.0 T: 2°CAssay Description:Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2014
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataKi:  400nMAssay Description:Binding affinity against Acetylcholinesterase of purified Octopus brain (OB)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataKi:  790nMAssay Description:Dissociation constant for enzyme-inhibitor complex of human recombinant AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataKi:  800nMAssay Description:Inhibition of human erythrocytes recombinant AChE assessed as dissociation constant for enzyme-inhibitor complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataKi:  1.01E+3nMAssay Description:Inhibition constant using AChE or BuChE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataKi:  4.80E+3nMAssay Description:Competitive inhibition of human recombinant AChE using ATChCl as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2014
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataKi:  4.80E+3nMAssay Description:Inhibition of human erythrocytes recombinant AChE assessed as dissociation constant for enzyme-inhibitor-substrate complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of North Texas

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataKi:  4.80E+3nMAssay Description:Dissociation constant for enzyme-inhibitor-substrate complex of human recombinant AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataKi:  3.40E+5nMAssay Description:Compound was evaluated for irreversible inhibition of Horse serum ButyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Defence

Curated by ChEMBL
LigandPNGBDBM120262(Edrophonium Chloride, 3 | EDROPHONIUM CHLORIDE | E...)
Affinity DataKi:  1.98E+5nMAssay Description:Inhibition constant using AChE or BuChE.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2013
Entry Details Article
PubMed