BDBM29135 CHEMBL11608::cid_5610::p-Tyramine::tyramine

SMILES NCCc1ccc(O)cc1

InChI Key InChIKey=DZGWFCGJZKJUFP-UHFFFAOYSA-N

Data  11 KI  2 IC50  2 Kd  10 EC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 29135   

TargetBeta-secretase 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataKd:  2.00E+6nMAssay Description:Binding affinity to BACE1 by surface plasmon resonance methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetTyR1(Asiatic rice borer moth)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataEC50:  369nMAssay Description:Agonist activity at Chilo suppressalis (rice stem borer) tyramine receptor TyR1 expressed in HEK293 cells assessed as reduction in forskolin-induced ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTrace amine-associated receptor 1(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataEC50:  69nMAssay Description:Agonist activity at rat N-terminal FLAG-tagged TAAR1 expressed in HEK293 cells assessed as [3H]cAMP accumulation measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2B(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataKd:  7.94E+3nMAssay Description:Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataEC50:  2.60E+4nMAssay Description:Activity at SER3 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTrace amine-associated receptor 1(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataEC50:  76nMAssay Description:Agonist activity at recombinant human TAAR1 expressed in CHO-K1 cells assessed as increase in intracellular cAMP incubated for 30 mins by HTRF analys...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTrace amine-associated receptor 1(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataEC50:  990nMAssay Description:Agonist activity at human TAAR1 stably expressed in HEK293 cells incubated for 30 mins by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTrace amine-associated receptor 1(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataEC50:  30nMAssay Description:Agonist activity at rat TAAR1 stably expressed in HEK293 cells incubated for 30 mins by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTrace amine-associated receptor 1(Mouse)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataEC50:  280nMAssay Description:Agonist activity at mouse TAAR1 stably expressed in HEK293 cells incubated for 30 mins by cAMP assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTrace amine-associated receptor 1(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataEC50:  731nMAssay Description:Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGuanine nucleotide-binding protein subunit alpha-15(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataIC50: 2.99E+4nMMore data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetTrace amine-associated receptor 1(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataEC50:  178nMMore data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetTrace amine-associated receptor 1(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataIC50: 882nMMore data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetGuanine nucleotide-binding protein subunit alpha-15(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataEC50: >2.99E+4nMMore data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetTrace amine-associated receptor 1(Human)
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataKi:  34nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataKi:  72.5nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataKi:  106nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataKi:  1.56E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataKi:  5.90E+3nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(2) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataKi: >1.70E+4nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataKi:  2.30E+4nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetD(4) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataKi: >3.50E+4nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article

TargetD(2) dopamine receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataKi:  1.60E+5nMAssay Description:Affinity towards Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataKi:  3.90E+5nMAssay Description:Affinity towards Dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPhenylethanolamine N-methyltransferase(Bovine)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | tyramine | p-Tyramine)
Affinity DataKi:  2.94E+5nMAssay Description:The compound was tested for In vitro inhibitory activity against Phenylethanolamine N-Methyltransferase (PNMT)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed