BDBM10015 2-[3-(1-cyano-1-methylethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile::2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methyl-propanenitrile::ANASTROZOLE::CHEMBL1399::NSC719344::arimidex
SMILES CC(C)(C#N)c1cc(Cn2cncn2)cc(c1)C(C)(C)C#N
InChI Key InChIKey=YBBLVLTVTVSKRW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 10015
Affinity DataIC50: 15nMAssay Description:Inhibition of human placental microsome CYP19More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of aromatase in human breast tumorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of aromatase (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of aromataseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of aromatase in human JEG3 cells by scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1,2,6,7-3H ]androstenedione / androstenedione during aromatization. Afte...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inhibition of aromatase (unknown origin) transfected in human MCF7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of aromatase in human placental microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of aromatase (unknown origin)More data for this Ligand-Target Pair
TargetUDP-glucuronosyltransferase 1A4(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 4.72E+3nMAssay Description:Drug metabolism assessed as hecogenin-mediated inhibition of human recombinant UGT1A4-catalyzed anastrozole glucuronidation after 90 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of human aromatase using dibenzylfluorescein substrate preincubated for 30 mins measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMT: 2°CAssay Description:The classical 3H2O assay was used to measure the effect of the inhibitor compounds on aromatase activity using human placental microsomes.More data for this Ligand-Target Pair
Affinity DataKi: 0.130nMAssay Description:Competitive inhibition of human aromatase using dibenzylfluorescein substrate after 10 mins preincubation measured every 10 sec for 5 mins by Michael...More data for this Ligand-Target Pair