BDBM50206434 1,2-Anthraquinonediol::1,2-dihydroxy-9,10-anthraquinone::1,2-dihydroxyanthra-9,10-quinone::1,2-dihydroxyanthracene-9,10-dione::Alizarin B::Alizarin Red::CHEMBL55814::Turkey Red::US20230364057, Compound 256::alizarin

SMILES Oc1ccc2C(=O)c3ccccc3C(=O)c2c1O

InChI Key InChIKey=RGCKGOZRHPZPFP-UHFFFAOYSA-N

Data  3 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50206434   

TargetProtein arginine N-methyltransferase 1 [11-371](Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataIC50: 1.16E+6nMAssay Description:Inhibition of human recombinant GST-PRMT1 expressed in BL21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetRmtA(Emericella nidulans)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataIC50: 1.22E+6nMAssay Description:Inhibition of Aspergillus nidulans recombinant GST-RmtA expressed in BL21 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataIC50: 3.01E+4nMAssay Description:Inhibition of recombinant human MAO-A using kynuramine as substrate incubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of recombinant human MAO-B using benzylamine as substrate preincubated for 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2019
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGag-Pol polyprotein(HIV-1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of HIV1 reverse transcriptase polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetTransthyretin(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetDNA gyrase inhibitor(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataIC50: 3.75E+4nMAssay Description:SDFQ HTS primary assay using pAB1_FL905 was performed in 2 µL of (1 xDNA gyrase buffer: 20 mM Tris-Acetate pH 7.9, 50 mM KAc, 10 mM MgCl2, 2 mM DTT, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent

TargetDeath-associated protein kinase 1(Human)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of DAPK1 (1 to 285 residues) (unknown origin) expressed in Escherichia coli using KKLNRTLSFAEPG as substrate in presence of ATP by fluoro-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetPhosphoglycerate mutase 1(Human)
Ningbo University

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of His6-tagged human PGAM1 expressed in Escherichia coli BL21(DE3)pLysS cells assessed as decrease in autofluorescence from oxidation of N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCytochrome P450 1B1(Human)
Laval University

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataKi:  500nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in Escherichia coli coexpressing human NADPH-cytochrome P450 reductase using 7-ethoxyresorufin as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataKi:  1.15E+3nMAssay Description:Binding affinity to Bcl-2 after 30 mins by florescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology

Curated by ChEMBL
LigandPNGBDBM50206434(1,2-dihydroxyanthracene-9,10-dione | alizarin | 1,...)
Affinity DataKi:  1.62E+3nMAssay Description:Binding affinity to Mcl-1 after 30 mins by florescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed