BDBM50000829 6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenoxy)methyl)-1-methylquinolin-2(1H)-one::6-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-phenoxymethyl]-1-methyl-1H-quinolin-2-one::6-[3-Fluoro-5-(tetrahydro-pyran-4-yl)-phenoxymethyl]-1-methyl-1H-quinolin-2-one::CHEMBL20403::ZD-2138

SMILES COC1(CCOCC1)c1cc(F)cc(OCc2ccc3n(C)c(=O)ccc3c2)c1

InChI Key InChIKey=SLZBEPLWGGRZAY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50000829   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50000829(6-[3-Fluoro-5-(tetrahydro-pyran-4-yl)-phenoxymethy...)
Affinity DataIC50: 27nMAssay Description:Inhibition of 5-lipoxygenase from human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50000829(6-[3-Fluoro-5-(tetrahydro-pyran-4-yl)-phenoxymethy...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX1 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50000829(6-[3-Fluoro-5-(tetrahydro-pyran-4-yl)-phenoxymethy...)
Affinity DataIC50: 83nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50000829(6-[3-Fluoro-5-(tetrahydro-pyran-4-yl)-phenoxymethy...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50000829(6-[3-Fluoro-5-(tetrahydro-pyran-4-yl)-phenoxymethy...)
Affinity DataIC50: 20nMAssay Description:In vitro inhibition of leukotriene B4 synthesis in human whole blood by inhibiting 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50000829(6-[3-Fluoro-5-(tetrahydro-pyran-4-yl)-phenoxymethy...)
Affinity DataIC50: 330nMAssay Description:Potency to inhibit oxidation of arachidonic acid by recombinant human 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50000829(6-[3-Fluoro-5-(tetrahydro-pyran-4-yl)-phenoxymethy...)
Affinity DataIC50: 20nMAssay Description:Inhibition of 5-lipoxygenase in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Zhejiang Sci-Tech University

Curated by ChEMBL
LigandPNGBDBM50000829(6-[3-Fluoro-5-(tetrahydro-pyran-4-yl)-phenoxymethy...)
Affinity DataIC50: 300nMAssay Description:Inhibition of guinea pig leukotriene D4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed