BDBM50612246 M&B 22948::NSC-757885::ZAPRINAST::Zaprinast

SMILES CCCOc1ccccc1-c1nc2[nH]nnc2c(=O)[nH]1

InChI Key InChIKey=REZGGXNDEMKIQB-UHFFFAOYSA-N

Data  1 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50612246   

TargetG-protein coupled receptor 35(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50612246(ZAPRINAST | Zaprinast | M&B 22948 | NSC-757885)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human GPR35 by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetG-protein coupled receptor 35(Mouse)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50612246(ZAPRINAST | Zaprinast | M&B 22948 | NSC-757885)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at mouse GPR35 by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetG-protein coupled receptor 35(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50612246(ZAPRINAST | Zaprinast | M&B 22948 | NSC-757885)
Affinity DataEC50:  0.710nMAssay Description:Agonist activity at GPR-35 in human HT-29 cells by DMR assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50612246(ZAPRINAST | Zaprinast | M&B 22948 | NSC-757885)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human corpus cavernosum PDE5More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetG-protein coupled receptor 35(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50612246(ZAPRINAST | Zaprinast | M&B 22948 | NSC-757885)
Affinity DataKi:  612nMAssay Description:Competitive binding affinity to Nluc-fused human GPR35 expressed in CHO-K1 cells assessed as inhibition constant using furimazine as substrate incuba...More data for this Ligand-Target Pair
In DepthDetails
PubMed