BDBM50519385 SAR-245409::SAR245409::Voxtalisib::XL-765::XL765

SMILES CCn1c2nc(N)nc(C)c2cc(-c2cc[nH]n2)c1=O

InChI Key InChIKey=RGHYDLZMTYDBDT-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50519385   

TargetSerine/threonine-protein kinase mTOR(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 157nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 9nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 39nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 43nMAssay Description:Inhibition of PI3K p110delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 113nMAssay Description:Inhibition of PI3K p110beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 39nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using phosphatidylinositol as substrate in presence of ATP by luciferase-luciferin-coupled chemiluminescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 157nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 39nMAssay Description:Inhibition of PI3Kalpha (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 113nMAssay Description:Inhibition of PI3Kbeta (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 9nMAssay Description:Inhibition of PI3Kdelta (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 43nMAssay Description:Inhibition of PI3Kgamma (unknown origin) expressed in baculovirus expression system using L-alpha-phosphatidylinositol as substrate by luminescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 39nMAssay Description:Inhibition of P13Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 110nMAssay Description:Inhibition of P13Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 9nMAssay Description:Inhibition of P13Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 43nMAssay Description:Inhibition of P13Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50519385(SAR-245409 | SAR245409 | Voxtalisib | XL-765 | XL7...)
Affinity DataIC50: 160nMAssay Description:Inhibition of mTOR in HEK 293 cells incubated with anti-mTOR antibody for 1.5 hrs followed by compound addition for 10 mins and measured for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed