BDBM423689 US10508120, Compound I-144::US10577373, Compound I-144::US11046698, Compound I-144::US11414431, Compound I-10

SMILES CNc1cc(Nc2cccn(-c3ncccc3F)c2=O)nc2c(cnn12)C(=O)N[C@H]1C[C@H]1F

InChI Key InChIKey=FFJRAFFUQOURPS-UHFFFAOYSA-N

Data  1 IC50  10 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 423689   

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataKd: <0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataKd: <0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataKd: <0.200nMAssay Description:Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan assay (Dis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataKd: <0.200nMAssay Description:The binding reaction was assembled by combining 16 μl of DNA-tagged kinase extract, 3.8 μl liganded affinity beads, and 0.18 μl test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2022
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to JAK3 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to TYK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataKd:  0.0730nMAssay Description:Binding affinity to human wild type TYK2 JH2 domain (G556/D888) expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nimbus Therapeutics

Curated by ChEMBL
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataIC50: 68nMAssay Description:Inhibition of TYK2 in human PBMC cells assessed as IL-12 induced phosphorylation of STAT4 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2 [556-888](Human)
Nimbus Lakshimi

US Patent
LigandPNGBDBM423689(US10508120, Compound I-144 | US10577373, Compound ...)
Affinity DataKd:  0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2025
Entry Details
Go to US Patent