BDBM50000296 CHEMBL441765::CHEMBL482811::U-50488H::US11492374, ID 1::US11912716, Compound U50488
SMILES CN([C@@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1
InChI Key InChIKey=VQLPLYSROCPWFF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 163 hits for monomerid = 50000296
Affinity DataIC50: 370nMAssay Description:Opioid receptor kappa agonist potency was determined in vitro using rabbit vas deferens(LVD) preparationMore data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Compound was evaluated for the opioid receptor kappa affinity using guinea pig brain membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 96nMAssay Description:Binding affinity against opioid receptor kappa, in guinea pig brain membrane, using [3H]bremazocine as the radioligand.More data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Enhancement of [35S]GTP-gamma-S binding to human KOR expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 3.40nMAssay Description:Concentration required to enhance [35S]GTP-gamma-S, binding to human Opioid receptor kappa expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 9.30nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production after 30 mins b...More data for this Ligand-Target Pair
Affinity DataEC50: 3.40nMAssay Description:Binding potency at human kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 46nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding after 60 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 36nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 2.90nMAssay Description:Agonist activity at human KOPR expressed in CHO cells assessed as enhancement of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.640nMAssay Description:Displacement of [3H]U 69593 from rat recombinant kappa-type opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.40nMAssay Description:Binding affinity against Opioid receptor kappa 1 using [3H]U-69593 as a radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 631nMAssay Description:Agonist activity at human KOR expressed in EE-HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat central nervous system membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.99nMAssay Description:Displacement of [3H]dynorphin from human kappa opioid receptor expressed in C6 giloma cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 6.30nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as increase of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 5.70nMAssay Description:Agonist activity at human KOPR expressed in CHO cells assessed as [35S]GTPgammaS binding after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Human Opioid receptor kappa 1
mediated stimulation of [35S]- GTPgammaS binding in CHO cells (Agonist potency).More data for this Ligand-Target Pair
mediated stimulation of [35S]- GTPgammaS binding in CHO cells (Agonist potency).More data for this Ligand-Target Pair
Affinity DataIC50: 0.690nMAssay Description:Binding activity against human Opioid receptor kappa 1 using [3H]-U 50488 as a radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Effective concentration for activation of human Opioid receptor kappa 1 expressed in chinese hamster ovary cells to enhance [35S]GTP-gamma-S, bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Activation of human k-opioid receptor as increased [35S]GTPcS binding More data for this Ligand-Target Pair
Affinity DataEC50: 46nMAssay Description:Inhibitory activity in stimulating [35S]-GTP-gamma S binding mediated by the Opioid receptor kappa 1 in chinese Hamster Ovary (CHO) cell membranes wa...More data for this Ligand-Target Pair
Affinity DataEC50: 46nMAssay Description:Agonist activity at human opioid kappa receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 36nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 36nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 46nMAssay Description:Agonist activity at huma kappa opioid receptor expressed in CHO cells assessed as U50488-stimulated of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 36nMAssay Description:Displacement of [3H]DAMGO from human kappa opioid receptor expressed in CHO cell membrane after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.303nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.84E+3nMAssay Description:Agonist activity at human recombinant mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 36nMAssay Description:Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.14nMAssay Description:Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellumMore data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 36nMAssay Description:Activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 36nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.12nMAssay Description:Agonist activity at kappa opioid receptor in guinea pig ileum assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
Affinity DataIC50: 2.35nMAssay Description:Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contractionMore data for this Ligand-Target Pair
Affinity DataEC50: 36nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding after 60 mins by scintillation countingMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1(Rat)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataIC50: 2.15E+3nMAssay Description:Inhibition of [3H]naloxone binding to opioid receptor in presence of NaClMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1(Rat)
University of Innsbruck
Curated by ChEMBL
University of Innsbruck
Curated by ChEMBL
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of [3H]naloxone binding to opioid receptor in presence of NaClMore data for this Ligand-Target Pair
Affinity DataEC50: 4.20nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [33S]GTPgammaS binding after 60 mins by scintillati...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Tested for opioid receptor agonistic activity in guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 0.640nMAssay Description:Displacement of [3H]U 69593 from human recombinant kappa-opioid receptor expressed in CHO cells measured after 60 mins by scintillation counting meth...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Agonist activity at human KOR expressed in HEK293 cells assessed as inhibition of forskolin-induced adenylyl cyclase-mediated cAMP accumulation after...More data for this Ligand-Target Pair
Affinity DataIC50: 0.680nMAssay Description:Displacement of [3H]U 69593 from rat recombinant kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.692nMAssay Description:Agonist activity at recombinant human KOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP level preincubated for 15 to...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Agonist activity at human kappa opioid receptor expressed in HEK293 assessed as inhibition forskolin-induced cAMP accumulation after 15 mins by EIAMore data for this Ligand-Target Pair