BDBM50065457 EMD-1214063::MSC-2156119::MSC-2156119J::Tepotinib::US9403799, A14

SMILES CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1

InChI Key InChIKey=AHYMHWXQRWRBKT-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50065457   

TargetHepatocyte growth factor receptor(Human)
Merck Patent

US Patent
LigandPNGBDBM50065457(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Merck Patent

US Patent
LigandPNGBDBM50065457(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Merck Patent

US Patent
LigandPNGBDBM50065457(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Merck Patent

US Patent
LigandPNGBDBM50065457(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Merck Patent

US Patent
LigandPNGBDBM50065457(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Merck Patent

US Patent
LigandPNGBDBM50065457(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Merck Patent

US Patent
LigandPNGBDBM50065457(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Merck Patent

US Patent
LigandPNGBDBM50065457(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Affinity DataIC50: 100nMT: 2°CAssay Description:The test plates used are 96-well Flashplate® microtitre plates from Perkin Elmer (Cat. No. SMP200). The components of the kinase reaction describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Merck Patent

US Patent
LigandPNGBDBM50065457(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Affinity DataIC50: 12nMAssay Description:Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phosphorylation after 45 mins by electrochemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Patent

US Patent
LigandPNGBDBM50065457(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390) after 60 mins by anoff-chip mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Patent

US Patent
LigandPNGBDBM50065457(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Patent

US Patent
LigandPNGBDBM50065457(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of N-terminal His/SUMO tagged wild type human c-Met (1038 to 1346 residues) transfected in Escherichia coli using Tyr06 peptide as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck Patent

US Patent
LigandPNGBDBM50065457(EMD-1214063 | MSC-2156119 | MSC-2156119J | Tepotin...)
Affinity DataIC50: 4nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed