BDBM50062261 CHEMBL829::Dimethyl-(2-methyl-3-phenothiazin-10-yl-propyl)-amine::Methylpromazine::N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine::TRIMEPRAZINE::Temaril

SMILES CC(CN(C)C)CN1c2ccccc2Sc2ccccc12

InChI Key InChIKey=ZZHLYYDVIOPZBE-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50062261   

TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50062261(CHEMBL829 | Temaril | Dimethyl-(2-methyl-3-phenoth...)
Affinity DataIC50: 7.37E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM50062261(CHEMBL829 | Temaril | Dimethyl-(2-methyl-3-phenoth...)
Affinity DataKi:  1.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM50062261(CHEMBL829 | Temaril | Dimethyl-(2-methyl-3-phenoth...)
Affinity DataKi:  1.27E+5nMAssay Description:Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductase (linear competitive type)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed