BDBM50107609 5,10,15,20-tetra(1-methyl-4-pyridyl)-porphyrin::CHEMBL2170855::CHEMBL337559::TMPyP4

SMILES C[n+]1ccc(cc1)-c1c2ccc(n2)c(-c2cc[n+](C)cc2)c2ccc([nH]2)c(-c2cc[n+](C)cc2)c2ccc([nH]2)c(-c2cc[n+](C)cc2)c2ccc1n2

InChI Key InChIKey=ABCGFHPGHXSVKI-UHFFFAOYSA-O

Data  13 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50107609   

TargetFanconi anemia group J protein(Human)
National Institutes of Health, National Institutes of Health Biomedical Research Center

LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataIC50: 2.30E+3nMpH: 8.0Assay Description:Standard helicase reaction mixtures (20μl) containing 5 fmol of the indicated TP-G4 or OX-1-G2' DNA substrates or forked duplex DNA substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFanconi anemia group J protein(Human)
National Institutes of Health, National Institutes of Health Biomedical Research Center

LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataIC50: 2.90E+3nMpH: 8.0Assay Description:Standard helicase reaction mixtures (20μl) containing 5 fmol of the indicated TP-G4 or OX-1-G2' DNA substrates or forked duplex DNA substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFanconi anemia group J protein(Human)
National Institutes of Health, National Institutes of Health Biomedical Research Center

LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataIC50: 4.90E+3nMpH: 8.0Assay Description:Standard helicase reaction mixtures (20μl) containing 5 fmol of the indicated TP-G4 or OX-1-G2' DNA substrates or forked duplex DNA substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent DNA helicase DinG(Escherichia coli (strain K12))
National Institutes of Health, National Institutes of Health Biomedical Research Center

LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataIC50: 1.10E+3nMpH: 8.0Assay Description:Standard helicase reaction mixtures (20μl) containing 5 fmol of the indicated TP-G4 or OX-1-G2' DNA substrates or forked duplex DNA substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetATP-dependent DNA helicase DinG(Escherichia coli (strain K12))
National Institutes of Health, National Institutes of Health Biomedical Research Center

LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataIC50: 1.20E+3nMpH: 8.0Assay Description:Standard helicase reaction mixtures (20μl) containing 5 fmol of the indicated TP-G4 or OX-1-G2' DNA substrates or forked duplex DNA substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataEC50:  8.90E+3nMAssay Description:Inhibition of telomerase by TRAP-LIG assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataIC50: 6.25E+3nMAssay Description:Apparent telomerase inhibition by G-quadruplex mechanismMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataIC50: 8.00E+3nMAssay Description:Apparent telomerase inhibition by G-quadruplex mechanismMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataIC50: 6.25E+3nMAssay Description:Apparent telomerase inhibition by G-quadruplex mechanismMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataIC50: 147nMAssay Description:Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction follo...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataIC50: 60nMAssay Description:Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by te...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataIC50: 710nMAssay Description:Inhibition of human telomerase expressed in HEK293T cells in presence of primer (T2AG3)3 by primer extension assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataIC50: 550nMAssay Description:Inhibition of human telomerase expressed in HEK293T cells treated before telomerase elongation by telomeric repeat amplification protocol assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50107609(CHEMBL2170855 | CHEMBL337559 | TMPyP4 | 5,10,15,20...)
Affinity DataIC50: 740nMAssay Description:Inhibition of human telomerase expressed in HEK293T cells treated after telomerase elongation by telomeric repeat amplification protocol assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed