BDBM50063995 Bedaquiline::CHEBI:72292::TMC207
SMILES CN(C)CC[C@@](c1cccc2c1cccc2)([C@H](c3ccccc3)c4cc5cc(ccc5nc4OC)Br)O
InChI Key InChIKey=QUIJNHUBAXPXFS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 50063995
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
Affinity DataEC50: 1.50E+4nMAssay Description:Inhibition of fluorescently labelled tracer binding to human ERG by competitive binding assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human ERG by manual patch clamp electrophysiology assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes after 20 minsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of human ERG assessed as prolongation of QT intervalMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) after 20 minsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research-Hyderabad
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair