BDBM50606048 DORDAVIPRONE::Dordaviprone::NSC-350625::ONC201::Onc 201::Onc-201::Onc201::TIC-10::TIC10
SMILES Cc1ccccc1CN1C2=NCCN2C2=C(CN(Cc3ccccc3)CC2)C1=O
InChI Key InChIKey=VLULRUCCHYVXOH-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50606048
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysisMore data for this Ligand-Target Pair
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Sichuan University
Curated by ChEMBL
Sichuan University
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at human CLpP (57 to 277 amino acids) expressed in Escherichia coli using fluorogenic peptide AC-WLA-AMC as substrate incubated for ...More data for this Ligand-Target Pair
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Sichuan University
Curated by ChEMBL
Sichuan University
Curated by ChEMBL
Affinity DataKd: 2.82E+4nMAssay Description:Binding affinity to human CLpP assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam and testosterone as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS...More data for this Ligand-Target Pair
Affinity DataIC50: 7.73E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysisMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sichuan University
Curated by ChEMBL
Sichuan University
Curated by ChEMBL
Affinity DataIC50: 3.71E+3nMAssay Description:Inhibition of hERG expressed in HEK293 cells by automated patch clamp assayMore data for this Ligand-Target Pair
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Sichuan University
Curated by ChEMBL
Sichuan University
Curated by ChEMBL
Affinity DataEC50: 1.25E+4nMAssay Description:Activation of recombinant human CLpP using Ac-WLA-AMC as substrate preincubated for 60 mins followed by substrate addition by fluorescence based assa...More data for this Ligand-Target Pair