BDBM24567 (2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate::CHEMBL175247::Orlistat::THLP::Tetrahydrolipstatin::US9328123, Orlistat::Xenical
SMILES CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
InChI Key InChIKey=AHLBNYSZXLDEJQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 68 hits for monomerid = 24567
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 990nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenyl butyrate as substrate preincubated for 5 mins followed by substrate addition measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of trypsin-like activity of 20S proteasome in human red blood cells pretreated for 20 mins followed by Boc-Leu-Arg-Arg-AMC substrate addit...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human red blood cells pretreated for 20 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of caspase-like activity of 20S proteasome in human red blood cells pretreated for 20 mins followed by Z-Leu-Leu-Glu-AMC substrate additio...More data for this Ligand-Target Pair
Affinity DataIC50: 4.63E+3nMAssay Description:Inhibition of human FAS thioster domain preincubated for 30 mins followed by 4-methylumbelliferyl heptanoate substrate addition measured every 5 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
TargetPancreatic triacylglycerol lipase(Human)
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human pancreatic lipase using emulsified olive oil as substrate pretreated with substrate for 5 mins followed by enzyme addition and me...More data for this Ligand-Target Pair
TargetPancreatic triacylglycerol lipase(Human)
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Affinity DataIC50: 806nMAssay Description:Compound was tested for inhibition of porcine pancreatic lipaseMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of porcine pancreatic lipase using micellar solution of triolein as substrate preincubated for 5 mins before substrate addition measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate preincubated for 15 mins prior substrate addition measured after 15 ...More data for this Ligand-Target Pair
Affinity DataIC50: 990nMAssay Description:Inhibition of porcine pancreatic lipase assessed as reduction in 4-nitrophenol formation from 4-nitrophenyl butyrate substrate preincubated for 30 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant DAGLbeta overexpressed in african green monkey COS7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant DAGLalpha overexpressed in african green monkey COS7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+3nMpH: 7.4 T: 2°CAssay Description:The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of human ABHD6 expressed in HEK293 cells using TAMRA-FP as substrate by SDS-PAGE gel based competitive ABPP assayMore data for this Ligand-Target Pair
TargetPancreatic triacylglycerol lipase(Human)
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Negative allosteric modulator activity at human Pancreatic lipase using DDAO-ol as fluorescent substrate preincubated for 3 mins followed by substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of porcine pancreatic lipase measured after 40 mins by spectrophotocolorimetric enzymatic assayMore data for this Ligand-Target Pair
TargetPancreatic triacylglycerol lipase(Human)
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of pancreatic lipase (unknown origin) by spectrophotometeric analysisMore data for this Ligand-Target Pair
TargetPancreatic triacylglycerol lipase(Human)
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Affinity DataIC50: 780nMAssay Description:Inhibition of PTL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of ABHD16A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of porcine pancreatic lipase using pNPB as substrate measured after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by subs...More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Human)
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant PLA2g7 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probeMore data for this Ligand-Target Pair
TargetPancreatic triacylglycerol lipase(Human)
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human PL expressed in HEK293F cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by s...More data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:Inhibition of recombinant human LPL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by sub...More data for this Ligand-Target Pair
Affinity DataIC50: 423nMAssay Description:Inhibition of Sus scrofa (pig) pancreatic lipase type 2 using PNPB as substrate pre-incubated with enzyme for 5 min prior to substrate addition measu...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of porcine pancreatic lipase using p-NPB as substrate pretreated for 15 mins followed by substrate addition measured after 15 mins by spec...More data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of porcine pancreatic lipase using triolein as substrate measured after 10 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenyl butyrate as substrate after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenyl butyrate as substrate pretreated for 15 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center
Curated by ChEMBL
National Institutes of Health Chemical Genomics Center
Curated by ChEMBL
Affinity DataEC50: 2.82E+4nMAssay Description:Activation of human PXR expressed in human HepG2 (DPX-2) cells assessed as induction of CYP3A4 after 24 hrs by luminescent analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant KIAA1363 transfected in HEK293T cells by SDS-PAGE using rhodamine-tagged FP probeMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of human ABHD12 expressed in HEK293 cells pre-incubated for 10 mins before 2-AG substrate addition by HPLC methodMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of human ABHD12 expressed in HEK293 cells pre-incubated for 10 mins before 2-AG substrate addition by HPLC methodMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of human ABHD6 expressed in HEK293 cells at 1 uM pre-incubated for 10 mins before 2-AG substrate addition followed by rapid 40 fold compou...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of human ABHD6 expressed in HEK293 cells at 1 uM pre-incubated for 10 mins before 2-AG substrate addition followed by rapid 40 fold compou...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human ABHD6 expressed in HEK293 cells at 1 uM pre-incubated for 10 mins before 2-AG substrate addition followed by rapid 40 fold compou...More data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of porcine pancreatic lipase pre-incubated for 15 mins before p-nitrophenylbutyrate substrate addition by microplate reader based methodMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human ABHD6 expressed in HEK293 cells at 1 uM pre-incubated for 10 mins before 2-AG substrate addition followed by rapid 40 fold compou...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant DAGL-alpha-mediated sn-1-[14C]oleoyl-2-arachidonoyl-glycerol hydrolysis to 2-AG overexpressed in african green monkey...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center
Curated by ChEMBL
National Institutes of Health Chemical Genomics Center
Curated by ChEMBL
Affinity DataEC50: 1.60E+3nMAssay Description:Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate assessed as formation of p-nitrophenol preincubated for 15 mins foll...More data for this Ligand-Target Pair
Affinity DataIC50: 2.03E+5nMAssay Description:Inhibition of FASN in human PANC1 cells assessed as inhibition of [14C]acetate incorporation preincubated for 4 hrs before [14C]acetate addition meas...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of human ABHD12 containing pCMV6-XL4-hABHD12 transfected into HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of human ABHD6 containing pCMV6-AC-hABHD6 transfected into HEK293 cellsMore data for this Ligand-Target Pair
TargetPancreatic triacylglycerol lipase(Human)
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Csir - National Institute For Interdisciplinary Science and Technology (Csir-Niist)
Curated by ChEMBL
Affinity DataIC50: 80.7nMAssay Description:Inhibition of pancreatic lipase assessed as umoles of oleic acic released per millimiter of triolein per hourMore data for this Ligand-Target Pair