BDBM50452855 Isoptpo Hyoscine::Scopolamine

SMILES [H][C@@]12O[C@@]1([H])[C@]1([H])C[C@@H](C[C@@]2([H])N1C)OC(=O)[C@H](CO)c1ccccc1

InChI Key InChIKey=STECJAGHUSJQJN-UHFFFAOYSA-N

Data  10 KI  16 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50452855   

LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]QNB from Muscarinic acetylcholine receptor of rat brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2018
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 6.59E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 6.59E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human SP/Myc epitope-tagged muscarinic M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced RLuc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 5.40nMAssay Description:Antagonist activity at human SP/Myc epitope-tagged muscarinic M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced RLuc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 0.575nMAssay Description:Antagonist activity at human SP/Myc epitope-tagged muscarinic M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced mVen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at human SP/Myc epitope-tagged muscarinic M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced mVen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2019
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Istituto De Angeli

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKd:  0.75nMAssay Description:In vitro receptor binding against Muscarinic acetylcholine receptor M1 in rat cerebral cortex was determined using [3H]pirenzepineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 4nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 4nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of ZnMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 1.30nMAssay Description:Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by beta-arrestin engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Istituto De Angeli

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKd:  3nMAssay Description:In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Rat)
Istituto De Angeli

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKd:  0.650nMAssay Description:In vitro receptor binding against Muscarinic acetylcholine receptor M3 in rat submandibular gland was determined using [3H]pirenzepineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 4.40nMAssay Description:Antagonist activity at human M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at human M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based beta-arrestin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 3.80nMAssay Description:Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein eng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 3.80nMAssay Description:Antagonist activity at human M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein act...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at human M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced response by BRET based Gq protein eng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2016
Entry Details Article
PubMed
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of [3H]pirenzepine binding to muscarinic receptor in rat cortical homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2018
Entry Details

TargetMuscarinic receptor M1(Bovine)
Groningen University Hospital

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKi:  0.410nMAssay Description:Binding affinity towards Muscarinic acetylcholine receptor M1 was determined in calf brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Istituto De Angeli

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKi:  0.530nMAssay Description:Binding affinity towards rat Muscarinic acetylcholine receptor M1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-NMS from wild-type human muscarinic M5 receptor expressed in CHO-K1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Istituto De Angeli

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKi:  4.60nMAssay Description:Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of W£Rzburg

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed