BDBM50033369 AMANTADINE::CHEMBL660::SYMADINE::SYMMETREL
SMILES NC12CC3CC(CC(C3)C1)C2
InChI Key InChIKey=DKNWSYNQZKUICI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 50033369
Affinity DataEC50: 660nMAssay Description:Inhibition of wild type Influenza A virus (A/chicken/Hubei/327/2004(H5N1)) M2 channel expressed in yeast after 46 to 48 hrs by yeast growth restorati...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 7.63E+4nMAssay Description:TP_TRANSPORTER: inhibition pramipexole uptake in rOCT1-injected oocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 3.78E+4nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKd: 2.17E+3nMAssay Description:Binding affinity to Influenza A virus A/Udorn/72 wild-type M2 proton channel by isothermal calorimetric titrationMore data for this Ligand-Target Pair
Affinity DataKd: 9.00E+3nMAssay Description:Binding affinity to Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes at pH 5.5 by two-electrode voltage c...More data for this Ligand-Target Pair
Affinity DataKd: 2.10E+5nMAssay Description:Binding affinity to Influenza A virus A/Udorn/72 M2 proton channel S31N mutant expressed in Xenopus laevis oocytes at pH 5.5 by two-electrode voltage...More data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes assessed as blockade of inward currents at...More data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes assessed as blockade of inward currents at...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Influenza A virus Udorn/72 M2 ion channel S31N mutant expressed in Xenopus oocyte plasma membranes after 2 mins by two-electrode voltag...More data for this Ligand-Target Pair
Affinity DataIC50: 2.71E+5nMAssay Description:TP_TRANSPORTER: inhibition pramipexole uptake in rOCT2-injected oocytesMore data for this Ligand-Target Pair
Affinity DataKd: 1.20E+4nMAssay Description:Binding affinity to Influenza A virus M2 transmembrane domain by analytical ultracentrifugation methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.61E+4nMAssay Description:Inhibition of Influenza A virus wild type M2 proton channel infected in Xenopus laevis oocytes after 2 mins by TEVC assayMore data for this Ligand-Target Pair
Affinity DataKd: 320nMAssay Description:Binding affinity to Influenza A Weybridge(H7N7) virus Matrix protein 2 by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of eGFP-tagged rat GluN1-1a/GluN2A transfected in human tsA201 cells assessed as inhibition glutamate-induced current measured at -65 mV h...More data for this Ligand-Target Pair
Affinity DataIC50: 3.96E+4nMAssay Description:Inhibition of OCT1(unknown origin)-mediated ASP+ uptake in HEK293 cells expressing OCT1 using ASP+ as substrate incubated for 5 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.59E+4nMAssay Description:Inhibition of OCT2(unknown origin)-mediated ASP+ uptake in HEK293 cells expressing OCT2 using ASP+ as substrate incubated for 5 minsMore data for this Ligand-Target Pair
TargetMatrix protein 2(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
National and Kapodistrian University of Athens
Curated by ChEMBL
National and Kapodistrian University of Athens
Curated by ChEMBL
Affinity DataKd: 2.17E+3nMAssay Description:Binding affinity to C-terminal amidated influenza A virus A/Udorn/72 (H3N2) M2 transmembrane domain (22 to 46 residues) in DPC micelles at pH 8 asses...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:TP_TRANSPORTER: inhibition of Dopamine uptake (Dopamine: 200 uM) in Xenopus laevis oocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expressed in xenopus oocytes after 2 mins by two-electrode voltage clamp assa...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of wild type Influenza A virus (A/udorn/72(H3N2)) M2 channel expressed in Xenopus oocyte plasma membrane incubated for 2 mins measured ove...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+5nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+5nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+5nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+5nMAssay Description:TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligandMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataKi: 1.00E+4nMAssay Description:Displacement of [3H]-(+)-MK-801 from phencyclidine binding site of NMDA receptor in human frontal cortex after 22 hrs by scintillation counting analy...More data for this Ligand-Target Pair