BDBM4810 (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one::3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-indolin-2-one::CHEMBL276711::SU5146::SU5416::Semaxanib::US10189853, semaxanib::US11111252, Compound SU5416::US9422297, SU5416::cid_5329098
SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1
InChI Key InChIKey=WUWDLXZGHZSWQZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 86 hits for monomerid = 4810
Affinity DataIC50: 660nMAssay Description:In vitro inhibition of Mast/stem cell growth factor receptor (c-Kit kinase) expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of VEGF-induced VEGFR2 phosphorylation in human U251 cells overexpressing Flk-1 pretreated for 60 mins prior to VEGF addition measured aft...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of VEGFR2 in human U251 cells assessed as inhibition of VEGF-induced tyrosine phosphorylation incubated for 60 mins prior to VEGF-activati...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of c-Abl tyrosine kinase expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 1 (VEGFR-1) expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 3 [VEGFR-3(Flt-4)] expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of c-SRC kinase expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 884nMAssay Description:Inhibition of VEGFR induced autophosphorylation of human Vascular endothelial growth factor receptor 2 (VEGFR2) transfected in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Fibroblast growth factor receptor expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Insulin-like growth factor I receptor expressed in baculovirusMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Institute of Microbial Chemistry (Bikaken)
Curated by ChEMBL
Institute of Microbial Chemistry (Bikaken)
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of EGFR (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Tyrosine protein kinase receptor TIE-2 (Tek) expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Met proto-oncogene tyrosine kinase (c-Met) expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 84nMAssay Description:In vitro inhibition of Colony stimulating factor 1 receptor (CSF-1R) expressed in baculovirusMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Institute of Microbial Chemistry (Bikaken)
Curated by ChEMBL
Institute of Microbial Chemistry (Bikaken)
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Epidermal growth factor receptor (HER-1,ErbB) expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 3.79E+4nMAssay Description:In vitro inhibition of Platelet-derived growth factor receptor beta expressed in baculovirusMore data for this Ligand-Target Pair
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of VEGF-induced VEGFR2 autophosphorylation in human U251 cells incubated for 60 mins prior to VEGF-induction measured after 10 mins by pho...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of VEGFR2 tyrosine kinase activity in VEGF-stimulated human U251 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of VEGFR2 phosphorylation in human U251 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Inhibition of PDGFRbetaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Shiraz University of Medical Sciences
Curated by ChEMBL
Shiraz University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of recombinant human KDR incubated for 1 hr using Tyr1 substrate by fluorimetry based Z'-LYTE-Tyr1 Peptide assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of porcine brain tubulin polymerization by GTP-induced assemblyMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of VEGF-induced VEGFR2 activation in human U251 cells pretreated for 60 mins followed by VEGF addition and measured after 10 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of VEGF-induced VEGFR2 phosphorylation in human U251 cells preincubated for 60 mins followed by VEGF induction measured after 10 mins by E...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of VEGFR-2 in human U251 cells assessed as reduction in VEGF induced phosphorylation preincubated for 60 mins followed by VEGF addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 12.9nMAssay Description:RTK inhibitory activity of the compounds 2-12 were evaluated using human tumor cells known to express high levels of EGFR, VEGFR-2 or PDFGR-β us...More data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of VEGFR2 in human U251 cells pretreated for 60 mins measured after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of VEGFR2 expressed in human A431 cellsMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Milano-Bicocca
Curated by ChEMBL
University of Milano-Bicocca
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of ALK by ELISA-based kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of ABL by ELISA-based kinase assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Shiraz University of Medical Sciences
Curated by ChEMBL
Shiraz University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of FLT3 by ELISA-based kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of GST-Flt1 kinase domain (unknown origin) expressed in baculovirus infected Sf9 cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KDR (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of Flt4 (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
Institute of Microbial Chemistry (Bikaken)
Curated by ChEMBL
Institute of Microbial Chemistry (Bikaken)
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of PDGFR-alpha (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of PDGFR-beta (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 2.00E+3nMAssay Description:For ISV disruption, the EC50 represents the concentration when the formation of about 50% of the ISVs is inhibited.More data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
Affinity DataIC50: 8.02E+4nMpH: 7.5Assay Description:Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
Institute of Microbial Chemistry (Bikaken)
Curated by ChEMBL
Institute of Microbial Chemistry (Bikaken)
Curated by ChEMBL
Affinity DataIC50: 1.66E+4nMpH: 7.5Assay Description:Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...More data for this Ligand-Target Pair
TargetOxytocin receptor(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataEC50: 1.15E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataEC50: 1.21E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair