BDBM50439621 GANETESPIB::STA-9090

SMILES CC(C)c1cc(-c2n[nH]c(=O)n2-c2ccc3n(C)ccc3c2)c(O)cc1O

InChI Key InChIKey=RVAQIUULWULRNW-UHFFFAOYSA-N

Data  10 IC50  1 Kd

PDB links: 3 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50439621   

TargetHeat shock protein 75 kDa, mitochondrial(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50439621(STA-9090 | GANETESPIB)
Affinity DataIC50: 51nMAssay Description:Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndoplasmin(Dog)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50439621(STA-9090 | GANETESPIB)
Affinity DataIC50: 10nMAssay Description:Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50439621(STA-9090 | GANETESPIB)
Affinity DataIC50: 63nMAssay Description:Inhibition of Hsp90 in human MG63 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50439621(STA-9090 | GANETESPIB)
Affinity DataIC50: 63nMAssay Description:Inhibition of Hsp90 in human MG63 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)

Curated by ChEMBL
LigandPNGBDBM50439621(STA-9090 | GANETESPIB)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant HSP90alpha (unknown origin) incubated for 24 hrs in presence of 1-FITC3 probe by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein 75 kDa, mitochondrial(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50439621(STA-9090 | GANETESPIB)
Affinity DataIC50: 38nMAssay Description:Inhibition of TRAP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEndoplasmin(Human)
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)

Curated by ChEMBL
LigandPNGBDBM50439621(STA-9090 | GANETESPIB)
Affinity DataIC50: 38nMAssay Description:Inhibition of GRP94 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50439621(STA-9090 | GANETESPIB)
Affinity DataKd:  24nMAssay Description:Binding affinity to HSP90 (unknown origin) by fluorescence quenching methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50439621(STA-9090 | GANETESPIB)
Affinity DataIC50: 5.39E+3nMAssay Description:Inhibition of human HSP90More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] A(Mouse)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM50439621(STA-9090 | GANETESPIB)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MAO A in mouse GL26 cells preincubated for 20 mins followed by 14C-labeled 5-hydroxytryptamine addition and measured after 20 mins by s...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Daegu-Gyeongbuk Medical Innovation Foundation (Dgmif)

Curated by ChEMBL
LigandPNGBDBM50439621(STA-9090 | GANETESPIB)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant HSP90alpha preincubated for 30 mins followed by FITC-GM addition and mesured after 3 hrs by fluorescence polarization...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)