BDBM50182403 (2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-yl)-N4-hydroxy-2-isobutyl-3-propylsuccinamide::(2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-2-oxo-1-(3-phenoxybenzyl)azepan-3-yl)-2-propylsuccinamide::CHEMBL204357::SR-973

SMILES CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Oc3ccccc3)c2)C1=O)C(=O)NO

InChI Key InChIKey=WICQDDCNCVTFDX-UHFFFAOYSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50182403   

TargetAmyloid-beta precursor protein(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182403((2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-2-oxo-1-(3-p...)
Affinity DataIC50: 200nMAssay Description:Inhibition of beta-amyloid peptide production in CHO N9 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182403((2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-2-oxo-1-(3-p...)
Affinity DataKi:  4nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182403((2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-2-oxo-1-(3-p...)
Affinity DataKi:  5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182403((2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-2-oxo-1-(3-p...)
Affinity DataKi:  7nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182403((2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-2-oxo-1-(3-p...)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182403((2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-2-oxo-1-(3-p...)
Affinity DataKi:  21nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-2(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182403((2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-2-oxo-1-(3-p...)
Affinity DataKi:  190nMAssay Description:Inhibition of MMP10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182403((2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-2-oxo-1-(3-p...)
Affinity DataKi:  660nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182403((2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-2-oxo-1-(3-p...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed