BDBM103830 SPI-05::US11041859, Code SPI-05::US9791447, Compound SPI-05

SMILES Nc1ccc(\N=N\c2ccc(\C=C\c3ccc(cc3S(O)(=O)=O)\N=N\c3ccc(N)c4ccccc34)c(c2)S(O)(=O)=O)c2ccccc12

InChI Key InChIKey=BEOHKTZPLVXCFG-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 103830   

LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 1.97E+4nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSentrin-specific protease 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of SENP3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of SENP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of SENP1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetSentrin-specific protease 7(Human)
City of Hope

US Patent
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 4.60E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSentrin-specific protease 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 8.50E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSentrin-specific protease 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 1.33E+4nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 4.60E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSmall ubiquitin-related modifier 1/2(Human)
City of Hope

US Patent
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 7.50E+3nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSentrin-specific protease 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 6.00E+4nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 6.00E+4nMAssay Description:The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSentrin-specific protease 7(Human)
City of Hope

US Patent
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 4.60E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSentrin-specific protease 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 8.50E+3nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSentrin-specific protease 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 1.33E+4nMAssay Description:The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSentrin-specific protease 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 4.60E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSentrin-specific protease 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 7.50E+3nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSentrin-specific protease 2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM103830(SPI-05 | US9791447, Compound SPI-05 | US11041859, ...)
Affinity DataIC50: 1.97E+4nMpH: 7.4Assay Description:Assays were performedby incubating SENPs with various concentrations of the inhibitor (0−60 μM) at RT for 10 min in assay buffer (50 mM Tr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed