BDBM221070 SPHINX::US9695160, SPHINX::US9796707, Reference Compound SPHINX

SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCOCC1)C(F)(F)F

InChI Key InChIKey=FZCPNRVICXFZJR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 221070   

TargetSRSF protein kinase 1(Human)
Exonate

LigandPNGBDBM221070(US9695160, SPHINX | SPHINX | US9796707, Reference ...)
Affinity DataIC50: 880nMpH: 7.5 T: 2°CAssay Description:A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2017
Entry Details Article
PubMed
TargetSRSF protein kinase 1(Human)
Exonate

LigandPNGBDBM221070(US9695160, SPHINX | SPHINX | US9796707, Reference ...)
Affinity DataIC50: 440nMT: 2°CAssay Description:Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
Go to US Patent

TargetSRSF protein kinase 1(Human)
Exonate

LigandPNGBDBM221070(US9695160, SPHINX | SPHINX | US9796707, Reference ...)
Affinity DataIC50: 440nMAssay Description:Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetSRSF protein kinase 1(Human)
Exonate

LigandPNGBDBM221070(US9695160, SPHINX | SPHINX | US9796707, Reference ...)
Affinity DataIC50: 10nMAssay Description:Inhibition of SRPK1 (unknown origin) using SRSF1 Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRSRSRSRSRSNSRSRSY-OH) as substrate incubated for 10 mins in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetSRSF protein kinase 1(Human)
Exonate

LigandPNGBDBM221070(US9695160, SPHINX | SPHINX | US9796707, Reference ...)
Affinity DataIC50: 580nMAssay Description:Inhibition of recombinant human SRPK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed