BDBM50480379 CHEMBL553939::SNX-5422

SMILES CC1(C)Cc2c(c(nn2-c2ccc(C(N)=O)c(N[C@H]3CC[C@@H](CC3)OC(=O)CN)c2)C(F)(F)F)C(=O)C1

InChI Key InChIKey=NVGFSTMGRRADRG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50480379   

TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Serenex

Curated by ChEMBL
LigandPNGBDBM50480379(SNX-5422 | CHEMBL553939)
Affinity DataIC50: 61nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as pS6 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Serenex

Curated by ChEMBL
LigandPNGBDBM50480379(SNX-5422 | CHEMBL553939)
Affinity DataIC50: 11nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as pERK degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Serenex

Curated by ChEMBL
LigandPNGBDBM50480379(SNX-5422 | CHEMBL553939)
Affinity DataIC50: 13nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as Hsp70 induction after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Serenex

Curated by ChEMBL
LigandPNGBDBM50480379(SNX-5422 | CHEMBL553939)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as Her2 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed