BDBM15579 CHEMBL972::DEPRENYL::L-Deprenyl::N-methyl-N-[(2R)-1-phenylpropan-2-yl]prop-2-yn-1-amine::SLG::Selegiline::US8633208, Deprenyl::US9469653, Selegiline::methyl[(2R)-1-phenylpropan-2-yl]prop-2-yn-1-ylamine
SMILES C[C@H](Cc1ccccc1)N(C)CC#C
InChI Key InChIKey=MEZLKOACVSPNER-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 254 hits for monomerid = 15579
Affinity DataIC50: 6.73E+4nMpH: 7.4 T: 2°CAssay Description:The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 7.4 T: 2°CAssay Description:The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...More data for this Ligand-Target Pair
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibitory activity of compounds was evaluated by a homogeneous luminescent method, the MAO-Glo Assay (Promega), measuring the monoamine oxidase acti...More data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Inhibitory activity of compounds was evaluated by a homogeneous luminescent method, the MAO-Glo Assay (Promega), measuring the monoamine oxidase acti...More data for this Ligand-Target Pair
Affinity DataIC50: 9.70E+3nMAssay Description:A stock solution was prepared using a human MAO-B enzyme (purchased from Aldrich) and a Amplex Red monoamine oxidase assay kit according to a prepara...More data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:In vitro inhibitory activity on rat brain by monoamine oxidase A (MAO-A)More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Compound was evaluated for the time-dependence inhibition of MAO-B at 0 minute pre-incubation periodsMore data for this Ligand-Target Pair
Affinity DataIC50: 9.90nMAssay Description:Compound was evaluated for the time-dependence inhibition of MAO-B at 20 minutes pre-incubation periodsMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:In vitro inhibitory activity on rat brain MAO-B.More data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Compound was evaluated for the time-dependence inhibition of MAO-B at 30 minutes pre-incubation periodsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.76E+4nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus infected BT1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected BT1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus-infected BTI-TN-5B1-4 cell microsomes assessed as decrease in H2O2 production using p-...More data for this Ligand-Target Pair
Affinity DataIC50: 6.73E+4nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus-infected BTI-TN-5B1-4 cell microsomes assessed as decrease in H2O2 production using p-...More data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:Inhibition of MAO-B in rat liver homogenate using [14C]-phenylethylamine as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of MAO-A in rat liver homogenate using [14C]-5HT as substrate preincubated for 30 mins followed by substrate addition measured after 20 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 6.72E+4nMAssay Description:Inhibition of human recombinant MAOA expressed in BTI-TN-5B1-4 cells using p-tyramine substrate assessed as reduction in H2O2 productionMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells using p-tyramine substrate assessed as reduction in H2O2 productionMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inhibition of rat brain MAO-B using [14C]-phenylethylamine substrate after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human brain MAO-B using [14C]-phenylethylamine substrate after 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 944nMAssay Description:Inhibition of rat brain MAO-A using [14C]-5- hydroxytryptamine creatinine disulphate substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human brain MAO-A using [14C]-5- hydroxytryptamine creatinine disulphate substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of rat recombinant MAO-B expressed in baculovirus-infected insect cells using p-tyraimne substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus-infected insect cells using p-tyraimne substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.82E+3nMAssay Description:Inhibition of human recombinant MAO-B using p-tyramine as substrate assessed as production of H2O2 incubated for 15 mins prior to substrate addition ...More data for this Ligand-Target Pair
Affinity DataKd: 59nMAssay Description:Binding affinity to human recombinant microsomal MAO-B by ITCMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of MAO-A in rat whole brain homogenate in presence of selegilineMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human MAO-B expressed in baculovirus infected BTI insect cells preincubated for 15 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.36E+4nMAssay Description:Inhibition of human MAO-A expressed in baculovirus infected BTI insect cells preincubated for 15 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.02E+4nMAssay Description:Inhibition of human recombinant MAO-A using p-tyramine as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant MAO-B using benzylamine as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by fluo...More data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of human recombinant MAOBMore data for this Ligand-Target Pair
Affinity DataIC50: 4.79E+4nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human MAOB using benzylamine as substrate after 30 mins by Amplex red based spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 19.6nMAssay Description:Inhibition of human recombinant MAOBMore data for this Ligand-Target Pair
Affinity DataIC50: 6.73E+4nMAssay Description:Inhibition of human recombinant MAOAMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of recombinant human MAOA using p-tyramine as substrate assessed as H2O2 production preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
Affinity DataIC50: 2.89E+3nMAssay Description:Inhibition of recombinant human MAOB using p-tyramine as substrate assessed as H2O2 production preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
Affinity DataIC50: 6.73E+4nMAssay Description:Inhibition of human recombinant MAOA by fluorimetric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 19.6nMAssay Description:Inhibition of human recombinant MAOB by fluorimetric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of MAOB in rat liver homogenates preincubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.99E+5nMAssay Description:Inhibition of MAOA in rat liver homogenates preincubated for 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.99E+5nMAssay Description:Inhibition of MAO-A in rat liver homogenate after 60 mins by residual activity plotMore data for this Ligand-Target Pair
Affinity DataIC50: 2.01E+3nMAssay Description:Inhibition of MAO-B in rat liver homogenate after 60 mins by residual activity plotMore data for this Ligand-Target Pair
Affinity DataIC50: 321nMAssay Description:Inhibition of recombinant human microsomal MAO-B expressed in baculovirus-infected insect cells using p-tyramine as substrate assessed as H2O2 produc...More data for this Ligand-Target Pair
Affinity DataIC50: 516nMAssay Description:In vitro ability to inhibit Monoamine oxidase A activity in rat whole brain in vitroMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:In vitro ability to inhibit Monoamine oxidase B activity in rat whole brain in vitroMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant microsomal MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells using p-tyramine as substrate assessed as reduc...More data for this Ligand-Target Pair
Affinity DataIC50: 6.73E+4nMAssay Description:Inhibition of human recombinant microsomal MAO-A expressed in baculovirus infected BTI-TN-5B1-4 cells using p-tyramine as substrate assessed as reduc...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Competitive inhibition of MAOB in rat liver homogenate by spectrophotometricallyMore data for this Ligand-Target Pair