BDBM50010301 8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol(SKF 83566)::CHEMBL324017::SKF 83566

SMILES CN1CCc2cc(Br)c(O)cc2C(C1)c1ccccc1

InChI Key InChIKey=XFTVOHWWEQGXLS-UHFFFAOYSA-N

Data  9 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50010301   

TargetAdenylate cyclase type 2(Human)
University of Chemistry and Technology Prague

Curated by ChEMBL
LigandPNGBDBM50010301(SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phen...)
Affinity DataIC50: 5.71E+3nMAssay Description:Inhibition of human adenylate cyclase 2 expressed in ACdelta 3/6 knockout HEK293 cells assessed as cyclic AMP accumulation incubated for 30 min follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetD(1A) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50010301(SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phen...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50010301(SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phen...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50010301(SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phen...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2011
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50010301(SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phen...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50010301(SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phen...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to human D5 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50010301(SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phen...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 5A(Rat)
The Scripps Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50010301(SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phen...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 5B(Rat)
The Scripps Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50010301(SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phen...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2011
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Research Biochemicals

Curated by ChEMBL
LigandPNGBDBM50010301(SKF 83566 | CHEMBL324017 | 8-Bromo-3-methyl-5-phen...)
Affinity DataKi:  1.36E+3nMAssay Description:Binding affinity against dopamine receptor D2 by using [3H]spiperone as radioligand in caudate-putamen of monkeyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed