BDBM50047138 CHEMBL25074::N-(5-Chloro-7-methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-9-yl)-2,2-dimethyl-propionamide::SDZ-208-912::SDZ-HDC-912

SMILES CN1C[C@H](CC2[C@H]1Cc1c(Cl)[nH]c3cccc2c13)NC(=O)C(C)(C)C

InChI Key InChIKey=QXOFQMUQMXGKGQ-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50047138   

TargetD(2) dopamine receptor(Rat)
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50047138(SDZ-208-912 | CHEMBL25074 | SDZ-HDC-912 | N-(5-Chl...)
Affinity DataKi:  0.470nMAssay Description:Compound was tested for antagonistic activity against D2 receptor from rat striatum, used [3H]raclopride as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Maryland Psychiatric Research Center

Curated by PDSP Ki Database
LigandPNGBDBM50047138(SDZ-208-912 | CHEMBL25074 | SDZ-HDC-912 | N-(5-Chl...)
Affinity DataKi:  0.900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50047138(SDZ-208-912 | CHEMBL25074 | SDZ-HDC-912 | N-(5-Chl...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor from bovine hippocampus, used [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Maryland Psychiatric Research Center

Curated by PDSP Ki Database
LigandPNGBDBM50047138(SDZ-208-912 | CHEMBL25074 | SDZ-HDC-912 | N-(5-Chl...)
Affinity DataKi:  3.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Maryland Psychiatric Research Center

Curated by PDSP Ki Database
LigandPNGBDBM50047138(SDZ-208-912 | CHEMBL25074 | SDZ-HDC-912 | N-(5-Chl...)
Affinity DataKi:  3.60nMAssay Description:Compound was tested for agonistic activity against D2 receptor from cloned CHO cells, used [3H]U-86170 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed