BDBM50056401 2-diethylaminoethyl [2-methoxy-4-amino-5-chloro]benzoate::4-Amino-5-chloro-2-methoxy-benzoic acid 2-diethylamino-ethyl ester::CHEMBL287045::SDZ 205557::SDZ-205557

SMILES CCN(CC)CCOC(=O)c1cc(Cl)c(N)cc1OC

InChI Key InChIKey=FFNWMBDISAYHDC-UHFFFAOYSA-N

Data  24 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50056401   

Target5-hydroxytryptamine receptor 4(Guinea pig)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataIC50: 251nMAssay Description:Inhibition of 5-HT-evoked 5-HT4 receptor-mediated contractions in the guinea pig distal colon longitudinal muscle myenteric plexus (LMMP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataEC50: >1.00E+3nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity as increased response to electrical stimulation in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataIC50: 77nMAssay Description:5-hydroxytryptamine 4 receptor antagonist activity expressed as the concentration which produced a 50% reduction of 5-HT induced contraction in guine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

Target5-hydroxytryptamine receptor 4(Guinea pig)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataIC50: 77nMAssay Description:5-hydroxytryptamine 4 receptor antagonist activity, concentration which gave 50% reduction of the 5-HT-induced contractions in the guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  2.51nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 as radioligand in rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]GR-113808 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Cnrs Upr 9023

Curated by PDSP Ki Database
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Mouse)
Cnrs Upr 9023

Curated by PDSP Ki Database
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Mouse)
Cnrs Upr 9023

Curated by PDSP Ki Database
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Mouse)
Cnrs Upr 9023

Curated by PDSP Ki Database
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  6.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Mouse)
Cnrs Upr 9023

Curated by PDSP Ki Database
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  7.76nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  7.94nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Guinea pig)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  7.94nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  19.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  19.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  25.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  126nMAssay Description:Binding affinity at 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  205nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 receptor using [3H]BRL-43694 in rat posterior cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

Target5-hydroxytryptamine 1D receptor(Bovine)
Sandoz Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  2.51E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Pig)
Sandoz Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  3.98E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Bovine)
Sandoz Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi:  6.31E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Sandoz Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Bovine)
Sandoz Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Sandoz Pharma

Curated by PDSP Ki Database
LigandPNGBDBM50056401(SDZ-205557 | SDZ 205557 | 2-diethylaminoethyl [2-m...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2011
Entry Details Article
PubMed