BDBM50197834 2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-one::CHEMBL388956::SCH-546909::aristolactam AIIIa::aristololactam A IIIa

SMILES COc1c(O)cc2C(=O)Nc3cc4ccc(O)cc4c1c23

InChI Key InChIKey=PFXGXKFPTAJYHV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50197834   

TargetAurora kinase B(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(aristololactam A IIIa | SCH-546909 | 2,9-dihydroxy...)
Affinity DataIC50: 2.14E+3nMAssay Description:Inhibition of Aurora 2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(aristololactam A IIIa | SCH-546909 | 2,9-dihydroxy...)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(aristololactam A IIIa | SCH-546909 | 2,9-dihydroxy...)
Affinity DataIC50: 140nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(aristololactam A IIIa | SCH-546909 | 2,9-dihydroxy...)
Affinity DataIC50: 214nMAssay Description:Inhibition of CDC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(aristololactam A IIIa | SCH-546909 | 2,9-dihydroxy...)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(aristololactam A IIIa | SCH-546909 | 2,9-dihydroxy...)
Affinity DataIC50: 140nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(aristololactam A IIIa | SCH-546909 | 2,9-dihydroxy...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(aristololactam A IIIa | SCH-546909 | 2,9-dihydroxy...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of AUR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed