BDBM50007473 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-ethanone::CHEMBL10971::SCH-37370

SMILES [#6]-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12

InChI Key InChIKey=OZCVIUHHOUTJJN-UHFFFAOYSA-N

Data  3 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50007473   

TargetPlatelet-activating factor receptor(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50007473(CHEMBL10971 | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6...)
Affinity DataIC50: 610nMAssay Description:Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when ch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent neutral amino acid transporter B(0)AT2(Human)
Max Planck Institute of Psychiatry

Curated by ChEMBL
LigandPNGBDBM50007473(CHEMBL10971 | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6...)
Affinity DataIC50: 5.48E+4nMAssay Description:Inhibition of eGFP-tagged human B0AT2 expressed in HEK293 cells measured within 10 mins by [3H]proline uptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/11/2016
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50007473(CHEMBL10971 | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibitory concentration against farnesyltransferase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetPlatelet-activating factor receptor(Human)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50007473(CHEMBL10971 | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6...)
Affinity DataIC50: 840nMAssay Description:Inhibitory concentration against platelet activating factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50007473(CHEMBL10971 | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6...)
Affinity DataIC50: 100nMAssay Description:Inhibition constant against histamine H1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50007473(CHEMBL10971 | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6...)
Affinity DataKi:  320nMAssay Description:Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50007473(CHEMBL10971 | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6...)
Affinity DataKi:  320nMAssay Description:Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Rat)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50007473(CHEMBL10971 | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6...)
Affinity DataKi:  320nMAssay Description:Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article