BDBM50114418 8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic acid (3,5-dichloro-pyridin-4-yl)-amide::CHEMBL40200::N-(3,5-dichloropyridin-4-yl)-8-methoxy-2-(trifluoromethyl)quinoline-5-carboxamide::SCH-365351

SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2ccc(nc12)C(F)(F)F

InChI Key InChIKey=HBRLPTMZNRCNBL-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50114418   

TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50114418(N-(3,5-dichloropyridin-4-yl)-8-methoxy-2-(trifluor...)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of PDE11More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50114418(N-(3,5-dichloropyridin-4-yl)-8-methoxy-2-(trifluor...)
Affinity DataIC50: 20nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50114418(N-(3,5-dichloropyridin-4-yl)-8-methoxy-2-(trifluor...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE10More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50114418(N-(3,5-dichloropyridin-4-yl)-8-methoxy-2-(trifluor...)
Affinity DataIC50: 51nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50114418(N-(3,5-dichloropyridin-4-yl)-8-methoxy-2-(trifluor...)
Affinity DataIC50: 77nMAssay Description:Inhibition of rolipram binding to PDE4 in rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50114418(N-(3,5-dichloropyridin-4-yl)-8-methoxy-2-(trifluor...)
Affinity DataIC50: 51nMAssay Description:Inhibition of Phosphodiesterase 4 from human U937 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Schering-Plough

Curated by ChEMBL
LigandPNGBDBM50114418(N-(3,5-dichloropyridin-4-yl)-8-methoxy-2-(trifluor...)
Affinity DataIC50: 7nMAssay Description:Inhibition of rolipram binding to PDE4 of rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50114418(N-(3,5-dichloropyridin-4-yl)-8-methoxy-2-(trifluor...)
Affinity DataIC50: 51nMAssay Description:Inhibition of PDE4 in Homo sapiens (human) U937 cellsMore data for this Ligand-Target Pair
In DepthDetails Article