BDBM15458 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]-2-methoxypyrimidine::4-[4-(4-fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]-2-methoxypyrimidine::CHEMBL95692::SB-242235::SB242235

SMILES COc1nccc(n1)-c1c(ncn1C1CCNCC1)-c1ccc(F)cc1

InChI Key InChIKey=PDTYLGXVBIWRIM-UHFFFAOYSA-N

Data  1 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 15458   

LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 40nMAssay Description:The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2007
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 83nMAssay Description:Inhibition of PKCalpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 50nMAssay Description:Inhibition of JNK1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 20nMAssay Description:Inhibition of JNK 2 beta-2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 50nMAssay Description:Inhibition of ERK2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 19nMAssay Description:Inhibition of p38 alpha kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 17nMAssay Description:Inhibition of PKC-beta2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 100nMAssay Description:Inhibition of cdc2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 50nMAssay Description:Inhibition of cRaf kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 10nMAssay Description:Inhibition of p56 Lck kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHeat shock protein beta-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 160nMAssay Description:Inhibition of HSP27 phosphorylation in IL-1-alpha-stimulated HLF cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataIC50: 130nMAssay Description:Inhibition of p38alpha phosphorylation in IL-1-alpha-stimulated HLF cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM15458(SB-242235 | 4-[4-(4-fluorophenyl)-1-(piperidin-4-y...)
Affinity DataKi:  36nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed