BDBM50423246 CHEMBL245568::SB-649701

SMILES COc1ccc2nccc([C@@H]3CN(C4CCN(Cc5cc6ccccc6[nH]5)CC4)C(=O)O3)c2c1

InChI Key InChIKey=CUWYXEKZVGDQDJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50423246   

TargetC-C chemokine receptor type 8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423246(SB-649701 | CHEMBL245568)
Affinity DataIC50: 501nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in HUT78 cells assessed as I309-mediated migration by chemotaxis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423246(SB-649701 | CHEMBL245568)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in RBL cells assessed as inhibition of I-309-induced intracellular calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423246(SB-649701 | CHEMBL245568)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423246(SB-649701 | CHEMBL245568)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in RBL cells assessed as inhibition of I-309-induced intracellular calcium mobilization by FL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 8(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50423246(SB-649701 | CHEMBL245568)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human recombinant CCR8 expressed in Th2 cells assessed as I309 mediated migration by chemotaxis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed