BDBM50322650 (S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidinopentanoic acid::CHEMBL389348::N2-[(2,2-diphenylethoxy)acetyl]-L-arginine::SB-290157

SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6]-[#8]-[#6]-[#6](-c1ccccc1)-c1ccccc1)-[#6](-[#8])=O

InChI Key InChIKey=YZHFZKINFOMMIT-UHFFFAOYSA-N

Data  14 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50322650   

TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 125nMAssay Description:Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at human C3a receptor in human U937 cells assessed as inhibition of intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 1.26E+3nMAssay Description:Antagonist activity against C3AR in HMDMs assessed as inhibition of C3a-induced intracellular calcium release by Fluo-3 AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 1.25E+3nMAssay Description:Antagonist activity against C3AR in HMDMs assessed as inhibition of C3a-induced intracellular calcium release by Fluo-3 AM dye based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]-C3a from C3AR in HMDMs by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 125nMAssay Description:Displacement of [125I-C3a] from C3a receptor in human PBMC by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2010
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 501nMAssay Description:Inhibition of human C3a receptor expressed on HMC1 cells by SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 200nMAssay Description:Displacement of 125I-C3a from human C3aR expressed in RBL-2H3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 28nMAssay Description:Antagonist activity at human C3aR expressed in RBL-2H3 cells assessed as inhibition of C3a-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 540nMAssay Description:Antagonist at C3a receptor in human LAD2 cells assessed as inhibition of C3a-induced beta-hexosaminidase release preincubated for 30 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at C3a receptor in human MDM cells assessed as inhibition of C3a-induced intracellular calcium release preincubated for 30 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at C3a receptor in human MDM cells assessed as induction of intracellular calcium release measured at 1 sec interval for => 200 secs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataEC50: <1.00E+5nMAssay Description:Agonist activity at C3a receptor in human MDM cells assessed as induction of intracellular calcium release measured at 1 sec interval for => 200 secs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at C3a receptor in human MDM cells assessed as inhibition of C3a-induced intracellular calcium release preincubated for 30 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetC3a anaphylatoxin chemotactic receptor(Human)
The University of Queensland

Curated by ChEMBL
LigandPNGBDBM50322650((S)-2-(2-(2,2-diphenylethoxy)acetamido)-5-guanidin...)
Affinity DataIC50: 501nMAssay Description:Antagonist at C3a receptor in human LAD2 cells assessed as inhibition of C3a-induced beta-hexosaminidase release preincubated for 30 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed