BDBM50084959 11'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo-[2,3-f]indole-3,4'-piperidine](SB-224289)::4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl-1'-methylspiro[3,5,6,7-tetrahydro-2H-furo[2,3-f]indole-3,4'-(hexahydropyridine)]-5-ylmethanone::CHEMBL281350::SB-224289::US20240166639, Example SB9::[2'-Methyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-yl]-[3-(1-methyl-piperidine)-2,3,6,7-tetrahydro-1-oxa-5-aza-s-indacen-5-yl]-methanone

SMILES CN1CCC2(COc3cc4CCN(C(=O)c5ccc(cc5)-c5ccc(cc5C)-c5noc(C)n5)c4cc23)CC1

InChI Key InChIKey=ATQMRMGXINTJHV-UHFFFAOYSA-N

Data  41 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 45 hits for monomerid = 50084959   

Target5-hydroxytryptamine receptor 1B(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataIC50: 2nMAssay Description:Inhibition affinity against 5-HT-1B receptor in rat frontal cortex using radio binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition activity against 5-hydroxytryptamine 1A receptor in rat hippocampus membranes using radio binding assaysMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of 5-hydroxytryptamine reuptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition affinity against 5-HT-1D receptor in bovine caudate nucleus using radio binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Leukos Biotech

US Patent
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  5.92nMAssay Description:Serotonin 5-HT2A receptor competition binding experiments were carried out in a polypropilene 96-well plate. In each well was incubated 80 μg of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 1B(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  6.31nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  6.91nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  6.91nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  8.20nMAssay Description:Serotonin 5-HT1B receptor competition binding experiments were carried out in a polypropylene 96-well plate. In each well was incubated 5 μg of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 1B(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  10nMAssay Description:Affinity for 5-hydroxytryptamine 1B receptor subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1B(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  10nMAssay Description:In vitro binding affinity towards cloned human 5-HT1B receptor using [3H]5-carboximidotryptamine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  260nMAssay Description:Affinity for 5-hydroxytryptamine 1D receptor subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

Target5-hydroxytryptamine receptor 1D(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  501nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  537nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
University of Groningen

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  537nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  631nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  631nMAssay Description:Compound was tested for binding affinity against human 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was tested for binding affinity against Alpha-1A adrenergic receptor (rat submaxillary gland)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was tested for binding affinity against human cloned Beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was tested for binding affinity against Alpha-1B adrenergic receptor (rat liver, [3H] prazosin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was tested for binding affinity against Histamine H1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was tested for binding affinity towards Histamine H2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Mouse)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was tested for binding affinity against Alpha-2B adrenergic receptor (NG 108-15 cells) using [3H]RX-821002) as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was tested for binding affinity against human cloned Dopamine receptor D3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Pig)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was tested for binding affinity against piglet hippocampus 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was tested for binding affinity against human cloned Alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Affinity for 5-hydroxytryptamine 1A receptor subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetMuscarinic acetylcholine receptor M1(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was tested for binding affinity against human cloned Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was tested for binding affinity against human cloned Beta-2 adrenergic receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was tested for binding affinity against human cloned Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was tested for binding affinity against human cloned Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  1.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  1.35E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  1.58E+3nMAssay Description:Binding affinity for human 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  2.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  2.04E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  2.14E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  3.16E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >3.16E+3nMAssay Description:Compound was tested for binding affinity against human 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi:  5.01E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against human 5-hydroxytryptamine 1E receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1F(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084959(4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)pheny...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2012
Entry Details Article
PubMed