BDBM50045333 CHEBI:90705::SB-203580
SMILES C[S+]([O-])c1ccc(cc1)-c1nc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1
InChI Key InChIKey=CDMGBJANTYXAIV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 64 hits for monomerid = 50045333
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human GAKMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of p38a MAPK (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant GST-tagged p38alpha MAP kinase (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of p38alpha MAPK (unknown origin) using ATF-2 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of human recombinant p38alpha MAPK using Ulight-CFFKNIVTPRTPPPSQGK-amide as substrate measured after 30 mins by LANCE assay relative to co...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of p38alpha MAPK (unknown origin) using ATF-2 as substrate after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged P38 alpha MAPK expressed in baculovirus infected Sf9 insect cells using p38 peptide...More data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human JNK2More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human JNK3More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human TNIKMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human BRAFMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CITMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CK1epsilonMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human DMPKMore data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Competitive inhibition of p38alpha MAP kinase (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human NLKMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RIPK2More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human STK36More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human p38betaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CK1deltaMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of p38 alpha (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 2(Pneumocystis carinii)
Csir-Indian Institute of Integrative Medicine
Curated by ChEMBL
Csir-Indian Institute of Integrative Medicine
Curated by ChEMBL
Affinity DataIC50: 105nMAssay Description:Inhibition of MAPK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of p38 MAPK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of SAPK2a/p38 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 720nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 390nMAssay Description:Inhibition of amino terminal HA-tagged human RIPK2 transfected in mouse AML12 cells assessed as inhibition of autophosphorylation incubated for 24 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of p38-MAPK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of P38betaMAPK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of p38-MAPK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibitory activity against induction of IL-1-beta release in PBMCsMore data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Binding affinity to Streptomyces avidinii streptavidin by NMR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 105nMAssay Description:Inhibition of GAK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of rat P2X7 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human P2X7 receptorMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of full-length FLAG-6His-TEV tagged human RIP2 expressed in Sf9 cells assessed as reduction in autophosphorylation pre-incubated for 30 mi...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of full-length FLAG-6His-TEV tagged human RIP2 expressed in Sf9 cells by fluorescent polarization assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 251nMAssay Description:Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of RIP2K in MDP-stimulated HEK-293 cells over-expressing NOD2 assessed as IL8 secretionMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of RIP2K in Pam2CSK4-stimulated HEK-293 cells over-expressing TLR2 assessed as IL8 secretionMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of TNF-alpha production by lipopolysaccharide-stimulated human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of p38beta (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 22nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells SPR analysisMore data for this Ligand-Target Pair
Affinity DataKd: 2.20nMAssay Description:Binding affinity to wild type human biotin labelled p38 alpha (9 to 352 residues) expressed in sf21 insect cells assessed as dissociation rate consta...More data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Binding affinity to p38alpha MAP kinase (unknown origin) by NMR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 590nMAssay Description:Inhibitory activity against TNF-alpha release in PBM cellsMore data for this Ligand-Target Pair