BDBM19187 (2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl)amino]propanamide::CHEMBL396778::SAG::Safinamide::US9051240, (S)-(+)-2-[4-(3-Fluorobenzyloxy)-benzylamino]-propanamide
SMILES [H][C@@](C)(NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
InChI Key InChIKey=NEMGRZFTLSKBAP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 81 hits for monomerid = 19187
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant MAO-B expressed in insect cells using p-tyramine as substrate preincubated for 30 mins followed by substrate addition...More data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:Inhibition of human MAO-BMore data for this Ligand-Target Pair
Affinity DataIC50: 2.53E+4nMAssay Description:Inhibition of recombinant human MAOB using kynuramine as substrate measured for 30 mins by fluorescence spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI cells using p-tyramine as substrate by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 30 mins follo...More data for this Ligand-Target Pair
Affinity DataIC50: 249nMAssay Description:Inhibition of recombinant human MAO-B expressed in Sf9 cells using benzylamine as substrate preincubated for 15 mins followed by substrate addition f...More data for this Ligand-Target Pair
Affinity DataIC50: 6.74E+4nMAssay Description:Inhibition of recombinant human MAO-A expressed in Sf9 cells using p-tyramine as substrate preincubated for 15 mins followed by substrate addition fo...More data for this Ligand-Target Pair
Affinity DataIC50: 2.24E+5nMAssay Description:Inhibition of human recombinant MAO-A expressed in insect cells using p-tyramine as substrate preincubated for 30 mins followed by substrate addition...More data for this Ligand-Target Pair
Affinity DataIC50: 2.24E+5nMAssay Description:Inhibition of human MAO-AMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human microsomal MAO-B expressed in recombinant baculovirus infected insect BTI-TN-5B1-4 cells assessed as reduction in H2O2 production...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human microsomal MAO-B expressed in recombinant baculovirus infected insect BTI-TN-5B1-4 cells assessed as reduction in H2O2 production...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected insect cell microsomes using kynuramine as substrate measured after 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected insect cell microsomes using kynuramine as substrate measured after 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as decrease in H2O2 production using p-tyr...More data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as decrease in H2O2 production using p-tyr...More data for this Ligand-Target Pair
Affinity DataIC50: 2.59E+4nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as decrease in H2O2 production using p-tyr...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Reversible inhibition of human MAOBMore data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Inhibition of human MAO-B expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 30 mins followed by subst...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of Sprague-Dawley rat MAO-AMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human MAO-BMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of MAO-B (unknown origin) using kynuramine as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human MAO-B using kynuramine as substrate incubated for 30 mins by spectrophotometry analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant MAO-B assessed as reduction in 4-hydroxyquinoline formation using kynuramine as substrate incubated for 50 mins by sp...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human MAO-B expressed in Sf9 cells using p-tyramine as substrate preincubated for 15 mins followed by substrate addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MAO-A expressed in Sf9 cells using benzylamine as substrate preincubated for 15 mins followed by substrate addition a...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0230nMAssay Description:Inhibition of human MAO-B using p-tyramine as substrate incubated for 15 mins by Amplex red and horseradish peroxidase based fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant MAO-B expressed in supersomes assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate by...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of Sprague-Dawley rat MAO-BMore data for this Ligand-Target Pair
Affinity DataIC50: 2.59E+4nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus infected BTI-TN-5B1-4 insect cells using p-tyramine as substrate preincubated for 15 m...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant MAO-B using p-tyramine as substrate preincubated for 30 mins followed by substrate addition and measured after 1 hr b...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human MAO-AMore data for this Ligand-Target Pair
Affinity DataIC50: 8.16E+3nMAssay Description:Inhibition of recombinant human MAO-BMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of human recombinant MAO-B assessed as reduction in 4-hydroxyquinoline level using kynuramine as a substrate preincubated for 5 mins follo...More data for this Ligand-Target Pair
Affinity DataIC50: 163nMAssay Description:Inhibition of recombinant human MAO-B expressed in Sf9 cells preincubated for 15 min followed by addition of benzylamine and measured after 60 min by...More data for this Ligand-Target Pair
Affinity DataIC50: 2.81E+4nMAssay Description:Inhibition of recombinant human MAO-A expressed in Sf9 cells preincubated for 15 min followed by addition of p-tyramine and measured after 60 min by ...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI-TN- 5B1-4 insect cells using kynuramine as substrate preincubated for 10 ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MAO-A using pargyline as incubated for 20 mins measuring increase in emission signal at 310 nm multimode plate reader...More data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of human recombinant MAO-B using kynuramine as substrate incubated for 20 mins measuring increase in emission signal at 400 nm multimode p...More data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus-infected insect cells using p-tyraimne substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells assessed as reduction in H2O2 production using p-tyramine as...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant human MAO-B after 20 mins using 50 uM kynuramine as substrate by fluorescence spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Inhibition of recombinant human MAOB using benzylamine as substrate after 30 mins by Amplex red based spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human MAOA using p-tyramine as substrate after 30 mins by Amplex red based spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:Inhibition of rat brain mitochondria MAOB by radioenzymatic assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+5nMAssay Description:Inhibition of rat brain mitochondria MAOA by radioenzymatic assayMore data for this Ligand-Target Pair
Affinity DataKd: 187nMAssay Description:Binding affinity to human recombinant microsomal MAO-B by ITCMore data for this Ligand-Target Pair
Affinity DataEC50: 1.50E+4nMAssay Description:Inhibition of human recombinant soluble MAO-B assessed as thermal shift after 20 mins by SYPRO orange staining-based fluorescence assayMore data for this Ligand-Target Pair